Endoplasmic reticulum stress-induced apoptosis in the development of diabetes: is there a role for adipose tissue and liver

Diabetes mellitus (DM) is a multifactorial chronic metabolic disease characterized by hyperglycaemia. Several different mechanisms have been implicated in the development of the disease, including endoplasmic reticulum (ER) stress. ER stress is increasingly acknowledged as an important mechanism in...

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Bibliographic Details
Published in:Apoptosis (London) 2009-12, Vol.14 (12), p.1424-1434
Main Authors: van der Kallen, Carla J. H, van Greevenbroek, Marleen M. J, Stehouwer, Coen D. A, Schalkwijk, Casper G
Format: Article
Language:English
Subjects:
Adipose Tissue - physiopathology
Animals
Apoptosis
Biochemistry
Biomedical and Life Sciences
Biomedicine
Body fat
Cancer Research
Cell Biology
Diabetes and Apoptosis
Diabetes Mellitus - metabolism
Diabetes Mellitus - physiopathology
Endoplasmic Reticulum - physiology
Humans
Liver - physiopathology
Oncology
Stress, Physiological
Virology
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Summary:Diabetes mellitus (DM) is a multifactorial chronic metabolic disease characterized by hyperglycaemia. Several different mechanisms have been implicated in the development of the disease, including endoplasmic reticulum (ER) stress. ER stress is increasingly acknowledged as an important mechanism in the development of DM, not only for β-cell loss but also for insulin resistance. Accumulating evidence suggests that ER stress-induced apoptosis may be an important mode of β-cell loss and therefore important in the development of diabetes. Recent data also suggest a role of ER stress-induced apoptosis in liver and adipose tissue in relation to diabetes, but more extensive studies on human adipocyte and hepatocyte (patho)physiology and ER stress are needed to identify the exact interactions between environmental signals, ER stress and apoptosis in these organs.
ISSN:1360-8185
1573-675X
DOI:10.1007/s10495-009-0400-4