Glycine N-Methyltransferase and Regulation of S-Adenosylmethionine Levels

Methylation is a major biological process. It has been shown to be important in formation of compounds such as phosphatidylcholine, creatine, and many others and also participates in epigenetic effects through methylation of histones and DNA. The donor of methyl groups for almost all cellular methyl...

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Bibliographic Details
Published in:The Journal of biological chemistry 2009-08, Vol.284 (34), p.22507-22511
Main Authors: Luka, Zigmund, Mudd, S. Harvey, Wagner, Conrad
Format: Article
Language:English
Subjects:
Animals
Gene Expression Regulation, Enzymologic - genetics
Gene Expression Regulation, Enzymologic - physiology
Glycine N-Methyltransferase - chemistry
Glycine N-Methyltransferase - genetics
Glycine N-Methyltransferase - metabolism
Humans
Methylation
Minireviews
Models, Biological
Protein Structure, Secondary
S-Adenosylmethionine - metabolism
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Summary:Methylation is a major biological process. It has been shown to be important in formation of compounds such as phosphatidylcholine, creatine, and many others and also participates in epigenetic effects through methylation of histones and DNA. The donor of methyl groups for almost all cellular methylation reactions is S-adenosylmethionine. It seems that the level of S-adenosylmethionine must be regulated in response to developmental stages and metabolic changes, and the enzyme glycine N-methyltransferase has been shown to play a major role in such regulation in mammals. This minireview will focus on the latest discoveries in the elucidation of the mechanism of that regulation.
ISSN:0021-9258
1083-351X
DOI:10.1074/jbc.R109.019273