Prospective study of predictors of vitamin D status and survival in patients with colorectal cancer

In an earlier study, a 25-hydroxyvitamin D(3) (25(OH)D) score calculated from known predictors of vitamin D status significantly predicted plasma levels of 25(OH)D and the risk of colorectal cancer, but the influence of the 25(OH)D score on survival after diagnosis is unknown. We prospectively exami...

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Bibliographic Details
Published in:British journal of cancer 2009-09, Vol.101 (6), p.916-923
Main Authors: NG, K, WOLPIN, B. M, MEYERHARDT, J. A, WU, K, CHAN, A. T, HOLLIS, B. W, GIOVANNUCCI, E. L, STAMPFER, M. J, WILLETT, W. C, FUCKS, C. S
Format: Article
Language:English
Subjects:
Adult
Aged
Biological and medical sciences
Body Mass Index
Cancer research
Cardiovascular disease
Clinical Study
Colorectal cancer
Colorectal Neoplasms - blood
Colorectal Neoplasms - mortality
Epidemiology
Female
Gastroenterology. Liver. Pancreas. Abdomen
Hospitals
Humans
Male
Medical personnel
Medical research
Medical sciences
Middle Aged
Mortality
Nurses
Plasma
Prospective Studies
Public health
Questionnaires
Radiation
Risk factors
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Tumors
Vitamin D
Vitamin D - analogs & derivatives
Vitamin D - blood
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Summary:In an earlier study, a 25-hydroxyvitamin D(3) (25(OH)D) score calculated from known predictors of vitamin D status significantly predicted plasma levels of 25(OH)D and the risk of colorectal cancer, but the influence of the 25(OH)D score on survival after diagnosis is unknown. We prospectively examined the influence of post-diagnosis predicted 25(OH)D levels on mortality among 1017 participants in the Nurses' Health Study and Health Professionals Follow-Up Study who were diagnosed with colorectal cancer from 1986 to 2004. Colorectal cancer-specific and overall mortality according to quintiles of predicted 25(OH)D levels were assessed. Cox proportional hazards models were used to calculate hazard ratios (HRs) adjusted for other risk factors of survival. Higher predicted 25(OH)D levels were associated with a significant reduction in colorectal cancer-specific (P trend=0.02) and overall mortality (P trend=0.002). Compared with levels in the lowest quintile, participants with predicted 25(OH)D levels in the highest quintile had an adjusted HR of 0.50 (95% CI, 0.26-0.95) for cancer-specific mortality and 0.62 (95% CI, 0.42-0.93) for overall mortality. Higher predicted 25(OH)D levels after a diagnosis of colorectal cancer may be associated with improved survival. Further study of the vitamin D pathway in colorectal cancer is warranted.
ISSN:0007-0920
1532-1827
DOI:10.1038/sj.bjc.6605262