Amphetamine effects on startle gating in normal women and female rats

Background Dopamine agonists disrupt prepulse inhibition (PPI) of startle in male rodents. In humans, this is observed only in some studies. We reported that PPI was disrupted by d -amphetamine in men, but only among those with high basal PPI levels. Here, amphetamine effects on PPI were tested in n...

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Bibliographic Details
Published in:Psychopharmacologia 2009-05, Vol.204 (1), p.165-175
Main Authors: Talledo, Jo A., Sutherland Owens, Ashley N., Schortinghuis, Tijmen, Swerdlow, Neal R.
Format: Article
Language:English
Subjects:
Adult
Amphetamine - administration & dosage
Amphetamine - pharmacology
Amphetamines
Animals
Biological and medical sciences
Biomedical and Life Sciences
Biomedicine
Central Nervous System Stimulants - administration & dosage
Central Nervous System Stimulants - pharmacology
Cross-Over Studies
Dopamine - physiology
Dopamine Agonists - administration & dosage
Dopamine Agonists - pharmacology
Dose-Response Relationship, Drug
Double-Blind Method
Female
Females
Humans
Medical sciences
Neuropharmacology
Neurosciences
Nucleus Accumbens - physiology
Original Investigation
Pharmacology. Drug treatments
Pharmacology/Toxicology
Psychiatry
Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer
Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)
Psychology. Psychoanalysis. Psychiatry
Psychomotor Performance - drug effects
Psychomotor Performance - physiology
Psychopharmacology
Rats
Rats, Long-Evans
Rats, Sprague-Dawley
Reflex, Startle - drug effects
Reflex, Startle - physiology
Reflexes
Rodents
Species Specificity
Women
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Summary:Background Dopamine agonists disrupt prepulse inhibition (PPI) of startle in male rodents. In humans, this is observed only in some studies. We reported that PPI was disrupted by d -amphetamine in men, but only among those with high basal PPI levels. Here, amphetamine effects on PPI were tested in normal women and female rats. Materials and methods Acoustic startle and PPI were tested in normal women after placebo or 20 mg amphetamine, in a double-blind, crossover design, and in female rats after vehicle or 4.5 mg/kg amphetamine. Rats were from Sprague–Dawley (SD) and Long Evans (LE) strains that differ significantly in gene expression in PPI-regulatory circuitry, including levels of nucleus accumbens (NAC) catechol- O -methyl transferase (COMT) mRNA. Results Amphetamine was bioactive in humans based on quantitative autonomic and self-rating measures, but did not significantly change startle magnitude or PPI across all subjects. Amphetamine’s effects on PPI in women correlated significantly ( p  
ISSN:0033-3158
1432-2072
DOI:10.1007/s00213-008-1446-7