Carotid Artery Atherosclerosis, MRI Indices of Brain Ischemia, Aging, and Cognitive Impairment The Framingham Study

Carotid atherosclerosis has been associated with increased risk of stroke and poorer cognitive performance in older adults. The relation of carotid atherosclerosis to cognitive impairment and MRI indices of ischemia and aging in midlife is less clear. We studied 1975 Framingham Offspring Study parti...

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Bibliographic Details
Published in:Stroke (1970) 2009-05, Vol.40 (5), p.1590-1596
Main Authors: ROMERO, José R, BEISER, Alexa, SESHADRI, Sudha, BENJAMIN, Emelia J, POLAK, Joseph F, VASAN, Ramachandran S, AU, Rhoda, DECARLI, Charles, WOLF, Philip A
Format: Article
Language:English
Subjects:
Aged
Aging - physiology
Atherosclerosis (general aspects, experimental research)
Atherosclerosis - complications
Atherosclerosis - pathology
Atherosclerosis - psychology
Biological and medical sciences
Blood and lymphatic vessels
Brain - pathology
Brain Ischemia - complications
Brain Ischemia - pathology
Brain Ischemia - psychology
Cardiology. Vascular system
Carotid Arteries - pathology
Carotid Artery Diseases - complications
Carotid Artery Diseases - pathology
Carotid Artery Diseases - psychology
Carotid Artery, Common - diagnostic imaging
Carotid Artery, Common - pathology
Carotid Artery, Internal - diagnostic imaging
Carotid Artery, Internal - pathology
Carotid Stenosis - diagnostic imaging
Carotid Stenosis - pathology
Cognition Disorders - etiology
Cognition Disorders - psychology
Female
Humans
Magnetic Resonance Imaging
Male
Medical sciences
Memory - physiology
Neurology
Neuropsychological Tests
Psychomotor Performance - physiology
Regression Analysis
Risk Factors
Ultrasonography
Vascular diseases and vascular malformations of the nervous system
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Summary:Carotid atherosclerosis has been associated with increased risk of stroke and poorer cognitive performance in older adults. The relation of carotid atherosclerosis to cognitive impairment and MRI indices of ischemia and aging in midlife is less clear. We studied 1975 Framingham Offspring Study participants free of stroke and dementia with available carotid ultrasound, brain MRI, and neuropsychological testing. We related common and internal carotid artery intima-media thickness and internal carotid stenosis to large white matter hyperintensity (>1 SD above age-specific mean), total brain volume, hippocampal volume, silent cerebral infarcts, and neuropsychological measures of verbal memory, executive function, and nonverbal memory measures. We observed that internal carotid artery intima-media thickness, but not common carotid artery intima-media thickness, was associated with higher prevalence of silent cerebral infarcts (OR, 1.21; 95% CI, 1.03-1.43; P
ISSN:0039-2499
1524-4628
DOI:10.1161/STROKEAHA.108.535245