Cervical Shedding of Human T Cell Lymphotropic Virus Type I Is Associated with Cervicitis

Human T cell lymphotropic virus type I (HTLV-I) is sexually transmitted. The purpose of this study was to determine the prevalence and risk factors for cervical shedding of HTLV-I DNA among Peruvian sex workers. HTLV tax DNA was detected in cervical specimens from 43 (68%) of 63 HTLV-I–infected sex...

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Bibliographic Details
Published in:The Journal of infectious diseases 2002-12, Vol.186 (11), p.1669-1672
Main Authors: Zunt, Joseph R., Dezzutti, Charlene S., Montano, Silvia M., Thomas, Katherine K., Alarcón, Jorge O. V., Quijano, Eberth, Courtois, Barry N., Sánchez, Jorge L., Campos, Pablo, Gotuzzo, Eduardo, Guenthner, Patricia C., Lal, Renu B., Holmes, King K.
Format: Article
Language:English
Subjects:
Adult
Aged
Biological and medical sciences
Cervical mucus
Cervix Uteri - virology
Concise Communication
DNA, Viral - analysis
Female
HTLV-I Antibodies - blood
HTLV-I Infections - transmission
HTLV-I Infections - virology
Human T lymphotropic virus 1
Human T-lymphotropic virus 1 - isolation & purification
Human T-lymphotropic virus 1 - physiology
Human viral diseases
Humans
Infections
Infectious diseases
Medical sciences
Middle Aged
Peru
Polymerase Chain Reaction
Prevalence
Risk Factors
Sex Work
Sex workers
Sexual transmission
Sexually transmitted diseases
T lymphocytes
Uterine cervicitis
Uterine Cervicitis - virology
Viral diseases
Viral diseases of the genital and urinary system
Virus Shedding
Viruses
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Summary:Human T cell lymphotropic virus type I (HTLV-I) is sexually transmitted. The purpose of this study was to determine the prevalence and risk factors for cervical shedding of HTLV-I DNA among Peruvian sex workers. HTLV tax DNA was detected in cervical specimens from 43 (68%) of 63 HTLV-I–infected sex workers and in samples obtained during 113 (52%) of 216 clinic visits between 1993 and 1997. Detection of HTLV DNA was associated with the presence of ⩾30 polymorphonuclear cells (PMNs) within cervical mucus per 100× microscopic field (odds ratio [OR], 4.3, 95% confidence interval [CI], 1.8–10.1) and with the presence of cervical secretions (OR, 2.0; 95% CI 1.2–3.4). Hormonal contraceptive use (OR 1.7; 95% CI, 0.8–3.6) and concomitant cervical infection by Chlamydia trachomatis (OR, 1.5; 95% CI, 0.3–4.3) or Neisseria gonorrhoeae (OR, 1.1; 95% CI, 0.6–3.7) were not significantly associated with HTLV-I shedding. Our results suggest that cervicitis may increase cervical HTLV-I shedding and the sexual transmission of this virus
ISSN:0022-1899
1537-6613
DOI:10.1086/345364