Association between the presence of H pylori in the liver and hepatocellular carcinoma： A meta-analysis

AIM： To evaluate the arguments for and against the possible roles of H pylori in hepatocellular carcinoma （HCC）. METHODS： We performed a systematic review of all relevant studies published in the literature. A total of 103 clinical trials and reports were identified, but only 10 trials qualified und...

Full description

Saved in:
Bibliographic Details
Published in:World journal of gastroenterology : WJG 2008-01, Vol.14 (2), p.307-312
Main Authors: Xuan, Shi-Ying, Xin, Yong-Ning, Chen, An-Jin, Dong, Quan-Jiang, Qiang, Xin, Li, Ning, Zheng, Ming-Hua, Guan, Hua-Shi
Format: Article
Language:English
Subjects:
Carcinoma, Hepatocellular - epidemiology
Helicobacter Infections - epidemiology
Helicobacter pylori
Humans
Liver Neoplasms - epidemiology
Rapid Communication
Risk Factors
肝功能
肝细胞癌
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:AIM： To evaluate the arguments for and against the possible roles of H pylori in hepatocellular carcinoma （HCC）. METHODS： We performed a systematic review of all relevant studies published in the literature. A total of 103 clinical trials and reports were identified, but only 10 trials qualified under our selection criteria. A metaanalysis was carried out by a biostatistician according to the Cochrane Reviewers＇ Handbook recommended by The Cochrane Collaboration. RESULTS： Nine case-control studies and one retrospective cross sectional study were included in the final analysis. Overall the prevalence of H pylori infection was 53.3% （129 of 242） in cases and 10.4% （29 of 280） in controls, and the summary odds ratio for the association of H pylori infection with the risk for HCC （using the fixed-effects model, which accounted for the homogeneity across the 10 studies） was determined to be 13.63 （95% CI, 7.90-23.49）. CONCLUSION： Our analysis showed a positive association between F1 pylori infection and the risk of HCC, with an indication of possible publication bias and possible confounders due to study designs that showed results of less pronounced associations.
ISSN:1007-9327
2219-2840
DOI:10.3748/wjg.14.307