Adenosine receptor agonists for promotion of dermal wound healing

Wound healing is a dynamic and complex process that involves a well-coordinated, highly regulated series of events including inflammation, tissue formation, revascularization and tissue remodeling. However, this orderly sequence is impaired in certain pathophysiological conditions such as diabetes m...

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Bibliographic Details
Published in:Biochemical pharmacology 2009-04, Vol.77 (7), p.1117-1124
Main Authors: Valls, María D., Cronstein, Bruce N., Montesinos, M. Carmen
Format: Article
Language:English
Subjects:
Adenosine - analogs & derivatives
Adenosine - pharmacology
Adenosine - therapeutic use
Adenosine receptors
Angiogenesis
Animals
Associated diseases and complications
Biological and medical sciences
Diabetes. Impaired glucose tolerance
Diabetic Foot - drug therapy
Diabetic Foot - metabolism
Diabetic foot ulcer
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Etiopathogenesis. Screening. Investigations. Target tissue resistance
Granulation tissue
Humans
Impaired healing
Inflammation
Medical sciences
Neovascularization, Physiologic - drug effects
Neovascularization, Physiologic - physiology
Pharmacology. Drug treatments
Purinergic P1 Receptor Agonists
Receptors, Purinergic P1 - metabolism
Skin Diseases - drug therapy
Skin Diseases - metabolism
Wound Healing - drug effects
Wound Healing - physiology
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Summary:Wound healing is a dynamic and complex process that involves a well-coordinated, highly regulated series of events including inflammation, tissue formation, revascularization and tissue remodeling. However, this orderly sequence is impaired in certain pathophysiological conditions such as diabetes mellitus, venous insufficiency, chronic glucocorticoid use, aging and malnutrition. Together with proper wound care, promotion of the healing process is the primary objective in the management of chronic poorly healing wounds. Recent studies have demonstrated that A 2A adenosine receptor agonists promote wound healing in normal and diabetic animals and one such agonist, Sonedenoson, is currently being evaluated as a prospective new therapy of diabetic foot ulcers. We will review the mechanisms by which adenosine receptor activation affects the function of the cells and tissues that participate in wound healing, emphasizing the potential beneficial impact of adenosine receptor agonists in diabetic impaired healing.
ISSN:0006-2952
1873-2968
DOI:10.1016/j.bcp.2008.11.002