Genetic Enhancement of Stem Cell Engraftment, Survival, and Efficacy

Cell-based therapies for the prevention and treatment of cardiac dysfunction offer the potential to significantly modulate cardiac function and improve outcomes in patients with cardiovascular disease. To date several clinical studies have suggested the potential efficacy of several different stem c...

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Bibliographic Details
Published in:Circulation research 2008-06, Vol.102 (12), p.1471-1482
Main Authors: Penn, Marc S, Mangi, Abeel A
Format: Article
Language:English
Subjects:
Biological and medical sciences
Cardiology. Vascular system
Cell Communication
Cell Movement
Cell Survival
Chemokines - genetics
Chemokines - physiology
Chemokines - therapeutic use
Coronary heart disease
Endothelial Cells - transplantation
Endothelium, Vascular - injuries
Extracellular Matrix - physiology
Fundamental and applied biological sciences. Psychology
Gene Transfer Techniques
Genetic Therapy
Genetic Vectors - physiology
Graft Enhancement, Immunologic
Heart
Heart - physiology
Heart Diseases - surgery
Heart failure, cardiogenic pulmonary edema, cardiac enlargement
Humans
Integrins - physiology
Intercellular Signaling Peptides and Proteins - genetics
Intercellular Signaling Peptides and Proteins - physiology
Intercellular Signaling Peptides and Proteins - therapeutic use
Medical sciences
Myocytes, Cardiac - physiology
Neovascularization, Physiologic
Recombinant Proteins - therapeutic use
Regeneration
Stem Cell Transplantation
Vertebrates: cardiovascular system
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Summary:Cell-based therapies for the prevention and treatment of cardiac dysfunction offer the potential to significantly modulate cardiac function and improve outcomes in patients with cardiovascular disease. To date several clinical studies have suggested the potential efficacy of several different stem cell types; however, the benefits seen in clinical trials have been inconsistent and modest. In parallel, preclinical studies have identified key events in the process of cell-based myocardial repair, including stem cell homing, engraftment, survival, paracrine factor release, and differentiation that need to be optimized to maximize cardiac repair and function. The inconsistent and modest benefits seen in clinical trials combined with the preclinical identification of mediators responsible for key events in cell-based cardiac repair offers the potential for cell-based therapy to advance to cell-based gene therapy in an attempt to optimize these key events in the hope of maximizing clinical benefit. Below we discuss potential key events in cardiac repair and the mediators of these events that could be of potential interest for genetic enhancement of stem cell–based cardiac repair.
ISSN:0009-7330
1524-4571
DOI:10.1161/CIRCRESAHA.108.175174