Hormesis and medicine

Evidence is presented which supports the conclusion that the hormetic dose–response model is the most common and fundamental in the biological and biomedical sciences, being highly generalizable across biological model, endpoint measured and chemical class and physical agent. The paper provides a br...

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Bibliographic Details
Published in:British journal of clinical pharmacology 2008-11, Vol.66 (5), p.594-617
Main Author: Calabrese, Edward J.
Format: Article
Language:English
Subjects:
Animals
anxiolytic
Biological and medical sciences
biophosphonates
biphasic
Dose-Response Relationship, Drug
dose–response
erectile dysfunction
Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy
history of medicine
hormesis
hormetic
Humans
J‐shaped
Lethal Dose 50
Medical sciences
memory
Nervous system (semeiology, syndromes)
Neurology
No-Observed-Adverse-Effect Level
Ophthalmology
Pharmacology, Clinical - methods
Pharmacology. Drug treatments
prion
prostate
protein folding
retinal detachment
Retinopathies
Review
seizure
statins
stroke
Toxicology - methods
tumor cell proliferation
U‐shaped
Vascular diseases and vascular malformations of the nervous system
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Description
Summary:Evidence is presented which supports the conclusion that the hormetic dose–response model is the most common and fundamental in the biological and biomedical sciences, being highly generalizable across biological model, endpoint measured and chemical class and physical agent. The paper provides a broad spectrum of applications of the hormesis concept for clinical medicine including anxiety, seizure, memory, stroke, cancer chemotherapy, dermatological processes such as hair growth, osteoporosis, ocular diseases, including retinal detachment, statin effects on cardiovascular function and tumour development, benign prostate enlargement, male sexual behaviours/dysfunctions, and prion diseases.
ISSN:0306-5251
1365-2125
DOI:10.1111/j.1365-2125.2008.03243.x