Body size and breast cancer in a black population--The Barbados National Cancer Study

Objective To evaluate the relationship between body size and incident breast cancer in an African-origin Caribbean population. Methods This investigation is based on 222 incident breast cancer cases and 454 controls from the Barbados National Cancer Study (BNCS) in whom body size variables that incl...

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Bibliographic Details
Published in:Cancer causes & control 2009-04, Vol.20 (3), p.387-394
Main Authors: Nemesure, Barbara, Wu, Suh-Yuh, Hennis, Anselm, Leske, M. Cristina
Format: Article
Language:English
Subjects:
African Americans
African Continental Ancestry Group
Age
Barbados - epidemiology
Biomedical and Life Sciences
Biomedicine
Body Mass Index
Body Size
Body Weight
Breast cancer
Breast Neoplasms - epidemiology
Breast Neoplasms - ethnology
Breast Neoplasms - etiology
Breast Neoplasms - pathology
Cancer Research
Case-Control Studies
Circumferences
Diet Surveys
Epidemiology
Female
Genealogy
Genomes
Genomics
Hematology
Humans
Incidence
Life Style
Mammography
Middle Aged
Multivariate Analysis
Obesity
Obesity - complications
Obesity - epidemiology
Oncology
Original Paper
Population
Postmenopause
Predisposing factors
Public Health
Questionnaires
Research centers
Risk Factors
Surveys and Questionnaires
Waist-Hip Ratio - standards
Womens health
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Summary:Objective To evaluate the relationship between body size and incident breast cancer in an African-origin Caribbean population. Methods This investigation is based on 222 incident breast cancer cases and 454 controls from the Barbados National Cancer Study (BNCS) in whom body size variables that included height, weight, body-mass index (BMI), waist and hip circumferences (WC, HC), and waist-hip ratio (WHR) were compared. Multivariate-adjusted logistic regression analyses were performed and the findings are presented as odds ratios (ORs) with 95% confidence intervals (CI). Results Although 33% of cases and 39% of controls were obese (BMI >= 30 kg/m²), BMI was not found to be a significant predictor of breast cancer in the multivariate analyses. Tall stature increased risk among women >=50 years (OR = 2.16, 95% CI (1.02, 4.58)), and a dual effect with age was suggested for both WC and WHR (decreased risk for those aged =50 years). Conclusions Body size appears to influence the risk of breast cancer in this population of African origin. The BNCS data suggest that a few, but not all body size factors play a role in breast cancer risk, and that age may affect these relationships.
ISSN:0957-5243
1573-7225
1573-7225
DOI:10.1007/s10552-008-9253-3