Biomarker analysis in stage III-IV (M0) gastric cancer patients who received curative surgery followed by adjuvant 5-fluorouracil and cisplatin chemotherapy: epidermal growth factor receptor ( ) associated with favourable survival

The aim of this study was to analyse the impact of epidermal growth factor receptor (EGFR), thymidylate synthase (TS), dihydropyrimidine dehydrogenase (DPD), thymidine phosphorylase (TP), aurora kinase (ARK) A/B, and excision repair cross-complementing gene 1 (ERCC1) on the efficacy of adjuvant chem...

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Bibliographic Details
Published in:British journal of cancer 2009-03, Vol.100 (5), p.732-738
Main Authors: KIM, J.-S, KIM, M.-A, BANG, Y.-J, LEE, K.-U, CHOE, K.-J, KIM, N. K, KIM, T. M, LEE, S.-H, KIM, D.-W, IM, S.-A, KIM, T.-Y, KIM, W. H, YANG, H.-K, HEO, D. S
Format: Article
Language:English
Subjects:
Adenocarcinoma - genetics
Adenocarcinoma - mortality
Adenocarcinoma - pathology
Adenocarcinoma - therapy
Adolescent
Adult
Aged
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Biological and medical sciences
Biomarkers, Tumor - analysis
Biomarkers, Tumor - genetics
Chemotherapy, Adjuvant
Cisplatin - administration & dosage
Female
Fluorouracil - administration & dosage
Gastrectomy
Gastroenterology. Liver. Pancreas. Abdomen
Gene Expression Regulation, Neoplastic
Humans
Male
Medical sciences
Middle Aged
Neoplasm Staging
Receptor, Epidermal Growth Factor - genetics
Stomach Neoplasms - genetics
Stomach Neoplasms - mortality
Stomach Neoplasms - pathology
Stomach Neoplasms - therapy
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Survival Analysis
Translational Therapeutics
Treatment Outcome
Tumors
Young Adult
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Summary:The aim of this study was to analyse the impact of epidermal growth factor receptor (EGFR), thymidylate synthase (TS), dihydropyrimidine dehydrogenase (DPD), thymidine phosphorylase (TP), aurora kinase (ARK) A/B, and excision repair cross-complementing gene 1 (ERCC1) on the efficacy of adjuvant chemotherapy with 5-fluorouracil and cisplatin (FP) after curative gastric resection. Normal and cancer tissue were separately obtained from gastrectomy samples of 153 patients with AJCC stage III-IV (M0) who subsequently treated with adjuvant FP chemotherapy. TS, DPD, TP, ERCC1, and ARK proteins were measured by immunohistochemistry (IHC). EGFR expression was investigated using a standardized IHC with the EGFR PharmDx assay. Amplification of EGFR gene was analysed using fluorescent in situ hybridisation (FISH). In multivariate analysis, stage, ratio of positive to removed lymph nodes, and EGFR expression were significant prognostic factors for overall survival. Patients with higher EGFR expression had better overall survival than those with lower expression (relative risk: 0.475 (95% confidence interval, 0.282-0.791, P=0.005). Low EGFR expression might be a predictive marker for relapse in curative resected stage III-IV (M0) gastric cancer patients who received adjuvant FP chemotherapy.
ISSN:0007-0920
1532-1827
DOI:10.1038/sj.bjc.6604936