Pattern of cancer risk in persons with AIDS in Italy in the HAART era

A record-linkage study was carried out between the Italian AIDS Registry and 24 Italian cancer registries to compare cancer excess among persons with HIV/AIDS (PWHA) before and after the introduction of highly active antiretroviral therapy (HAART) in 1996. Standardised incidence ratios (SIR) were co...

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Bibliographic Details
Published in:British journal of cancer 2009-03, Vol.100 (5), p.840-847
Main Authors: DAL MASO, L, POLESEL, J, TAGLIABUE, G, ZANETTI, R, FEDERICO, M, LIMINA, R. M, MANGONE, L, DE LISI, V, STRACCIL, F, FERRETTI, S, PIFFER, S, BUDRONI, M, SERRAINO, D, DONATO, A, GIACOMIN, A, BELLU, F, FUSCO, M, MADEDDU, A, VITARELLI, S, TESSANDORI, R, TUMINO, R, SULIGOI, B, FRANCESCHI, S, LISE, M, PISELLI, P, FALCINI, F, RUSSO, A, INTRIERI, T, VERCELLI, M, ZAMBON, P
Format: Article
Language:English
Subjects:
Acquired immune deficiency syndrome
Acquired Immunodeficiency Syndrome - complications
Acquired Immunodeficiency Syndrome - drug therapy
Acquired Immunodeficiency Syndrome - epidemiology
Adolescent
Adult
Aged
AIDS
Antiretroviral Therapy, Highly Active
Biological and medical sciences
Cancer research
Cervical cancer
Drug therapy
Epidemiology
Female
HIV
HIV-1
Human immunodeficiency virus
Human viral diseases
Humans
Incidence
Infectious diseases
Italy - epidemiology
Kaposis sarcoma
Liver cancer
Lymphoma
Male
Medical research
Medical sciences
Medical screening
Middle Aged
Neoplasms - epidemiology
Neoplasms - etiology
Oncology
Public health
Registries
Risk Factors
Tumors
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
Young Adult
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Summary:A record-linkage study was carried out between the Italian AIDS Registry and 24 Italian cancer registries to compare cancer excess among persons with HIV/AIDS (PWHA) before and after the introduction of highly active antiretroviral therapy (HAART) in 1996. Standardised incidence ratios (SIR) were computed in 21951 AIDS cases aged 16-69 years reported between 1986 and 2005. Of 101 669 person-years available, 45 026 were after 1996. SIR for Kaposi sarcoma (KS) and non-Hodgkin lymphoma greatly decreased in 1997-2004 compared with 1986-1996, but high SIRs for KS persisted in the increasingly large fraction of PWHA who had an interval of
ISSN:0007-0920
1532-1827
DOI:10.1038/sj.bjc.6604923