Protective effects of electroacupuncture on acetylsalicylic acid-induced acute gastritis in rats

AIM： To investigate the protective effects of electroacupuncture （EA） pretreatment on acetylsalicylic acid （ASA）-induced ulceration in rats. METHODS： We randomly divided 72 rats into three groups including control （administered with distilled water）, ASA group （administered 100 mg/kg ASA） and EA gro...

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Published in:World journal of gastroenterology : WJG 2009-02, Vol.15 (8), p.973-977
Main Authors: Hwang, Hye-Suk, Han, Kyung-Ju, Ryu, Yeon-Hee, Yang, Eun-Jin, Kim, Yoo-Sung, Jeong, Sang-Yong, Lee, Young-Seop, Lee, Myeong-Soo, Koo, Sung-Tae, Choi, Sun-Mi
Format: Article
Language:English
Subjects:
Animals
ASA
Aspirin - toxicity
Brief
Cyclooxygenase 1 - genetics
Cyclooxygenase 2 - genetics
Disease Models, Animal
Electroacupuncture - methods
Gastric Acid - metabolism
Gastritis - chemically induced
Gastritis - pathology
Gastritis - prevention & control
Male
mRNA水平
Nitric Oxide - metabolism
NO水平
Rats
Rats, Sprague-Dawley
Reverse Transcriptase Polymerase Chain Reaction
RNA, Messenger - genetics
乙酰水杨酸
保护作用
急性胃炎
石油公司
阿司匹林
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Summary:AIM： To investigate the protective effects of electroacupuncture （EA） pretreatment on acetylsalicylic acid （ASA）-induced ulceration in rats. METHODS： We randomly divided 72 rats into three groups including control （administered with distilled water）, ASA group （administered 100 mg/kg ASA） and EA group （administered EA ＋ 100 mg/kg ASA）. Each rat was fasted for 18 to 24 h before experimentation, and lesion scores, gastric acidity, cyclooxygenase （COX）-1 and -2 mRNA levels, and total nitric oxide （NO） concentration were measured. RESULTS： The lesion scores of the EA group were significantly lower than those of the ASA group. Gastric acidity of the ASA and EA groups was reduced compared to the control group. COX-1 and -2 mRNA levels were significantly increased in the EA group as compared to the control and ASA groups, and NO levels were also significantly increased in the EA group as compared to the ASA group. CONCLUSION： These results suggest that EAmediated protection against ASA-induced ulceration in rats may occur via gastric defense components.
ISSN:1007-9327
2219-2840
DOI:10.3748/wjg.15.973