Airway glutathione homeostasis is altered in children with severe asthma: Evidence for oxidant stress

Background Severe asthma is characterized by persistent airway inflammation and increased formation of reactive oxygen species. Objectives Glutathione (GSH) is an important antioxidant in the epithelial lining fluid (ELF). We hypothesized that airway GSH homeostasis was altered in children with seve...

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Bibliographic Details
Published in:Journal of allergy and clinical immunology 2009, Vol.123 (1), p.146-152.e8
Main Authors: Fitzpatrick, Anne M., PhD, Teague, W. Gerald, MD, Holguin, Fernando, MD, Yeh, Mary, PhD, Brown, Lou Ann S., PhD
Format: Article
Language:English
Subjects:
8-isoprostanes
Adolescent
Adult
Airway management
Allergy and Immunology
Antioxidants - metabolism
Asthma
Asthma - metabolism
Biological and medical sciences
Biomarkers - metabolism
Bronchoalveolar Lavage Fluid
Child
Child, Preschool
children
Cough - metabolism
Dinoprost - analogs & derivatives
Dinoprost - metabolism
Female
Fundamental and applied biological sciences. Psychology
Fundamental immunology
glutathione
Glutathione - metabolism
Glutathione Peroxidase - metabolism
Glutathione Reductase - genetics
Glutathione Transferase - metabolism
Homeostasis
Humans
hydrogen peroxide
Hydrogen Peroxide - metabolism
Lung - metabolism
Male
malondialdehyde
Malondialdehyde - metabolism
Medical sciences
Oxidation-Reduction
Oxidative Stress
Pediatrics
Premature birth
redox potential
Rodents
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
Variables
Voice Disorders - metabolism
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Summary:Background Severe asthma is characterized by persistent airway inflammation and increased formation of reactive oxygen species. Objectives Glutathione (GSH) is an important antioxidant in the epithelial lining fluid (ELF). We hypothesized that airway GSH homeostasis was altered in children with severe asthma and was characterized by decreased GSH and increased glutathione disulfide (GSSG) concentrations. Methods Bronchoalveolar lavage was obtained from 65 children with severe asthma, including 35 children with baseline airway obstruction evidenced by FEV1
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2008.10.047