Hydrochalarones: A Novel Endohedral Metallofullerene Platform for Enhancing Magnetic Resonance Imaging Contrast

Targeted imaging requires contrast agents that remain in the vasculature for extended periods of time. A new contrast agent is described in which gadolinium is encapsulated within an extremely stable carbon sphere, thus allowing for safe extended residence. Water solubility and small particle size i...

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Bibliographic Details
Published in:Journal of medicinal chemistry 2008-07, Vol.51 (13), p.3681-3683
Main Authors: MacFarland, Darren K, Walker, Kenneth L, Lenk, Robert P, Wilson, Stephen R, Kumar, Krishan, Kepley, Christopher L, Garbow, Joel R
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Contrast Media - chemistry
Contrast Media - pharmacology
Contrast media. Radiopharmaceuticals
Fullerenes - chemistry
Fullerenes - pharmacology
Gadolinium - chemistry
Investigative techniques, diagnostic techniques (general aspects)
Magnetic Resonance Imaging - methods
Medical sciences
Mice
Mice, Inbred BALB C
Miscellaneous. Technology
Molecular Structure
Organ Specificity - drug effects
Pharmacology. Drug treatments
Radiodiagnosis. Nmr imagery. Nmr spectrometry
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Summary:Targeted imaging requires contrast agents that remain in the vasculature for extended periods of time. A new contrast agent is described in which gadolinium is encapsulated within an extremely stable carbon sphere, thus allowing for safe extended residence. Water solubility and small particle size is achieved with novel fullerene chemistry, attaching multiple oligoethylene glycol groups through nitrogen chemistry. These new compounds can be used to visualize tissue architecture in vivo with standard MRI techniques.
ISSN:0022-2623
1520-4804
DOI:10.1021/jm800521j