Quantification of mouse lung elastin during prenatal development

Elastic fibres play a crucial function during the process of lung alveolisation. During the perinatal period, any changes in the elastogenic process during foetal development may result in permanent lifetime defects. In pre-natal life, well-developed pulmonary elastic fibres should favor the pre-nat...

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Bibliographic Details
Published in:The open respiratory medicine journal 2008, Vol.2 (1), p.46-51
Main Authors: Rodrigues, Paula, Gonçalves, Carlos, Honório, Ana, Barros, José, Bairos, Vasco
Format: Article
Language:English
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Summary:Elastic fibres play a crucial function during the process of lung alveolisation. During the perinatal period, any changes in the elastogenic process during foetal development may result in permanent lifetime defects. In pre-natal life, well-developed pulmonary elastic fibres should favor the pre-natal maturation of the lung and an enhanced alveolisation, which in many species, such as humans begins only after birth. The authors present a quantitative study by image analysis and by high-pressure liquid chromatography (HPLC) of the mouse lungs' elastic fibre content from the 15th till the 19th gestational day.
ISSN:1874-3064
1874-3064
DOI:10.2174/1874306400802010046