Differential effect of marrow adiposity and visceral and subcutaneous fat on cardiovascular risk in young, healthy adults

Background: Adipose tissue is an endocrine organ that influences many metabolic processes and accumulates in different depots, including the bone marrow. While the negative associations between visceral fat (VF) or subcutaneous fat (SF) and cardiovascular disease (CVD) risks are well known, the rela...

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Bibliographic Details
Published in:International Journal of Obesity 2008-12, Vol.32 (12), p.1854-1860
Main Authors: Di Iorgi, N, Mittelman, S.D, Gilsanz, V
Format: Article
Language:English
Subjects:
adipose tissue
Adipose Tissue - anatomy & histology
Adipose Tissue - diagnostic imaging
Adipose tissues
Adolescent
Analysis
anthropometric measurements
Biological and medical sciences
Biomarkers - blood
Blood Pressure
Body fat
Body Mass Index
Body Size
bone marrow
Bone Marrow - anatomy & histology
Bone Marrow - diagnostic imaging
Cardiovascular disease
Cardiovascular diseases
Cardiovascular Diseases - etiology
Cross-Sectional Studies
Female
gender differences
Glucose
Health aspects
Hospitals
Humans
Insulin resistance
Intra-Abdominal Fat - anatomy & histology
Intra-Abdominal Fat - diagnostic imaging
Lipids
Los Angeles
Male
Medical sciences
men
Metabolic diseases
Metabolic disorders
Obesity
risk assessment
Risk Factors
subcutaneous fat
Subcutaneous Fat - anatomy & histology
Subcutaneous Fat - diagnostic imaging
Tomography
Tomography, X-Ray Computed
visceral fat
Waist-Hip Ratio
women
Young Adult
Young adults
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Summary:Background: Adipose tissue is an endocrine organ that influences many metabolic processes and accumulates in different depots, including the bone marrow. While the negative associations between visceral fat (VF) or subcutaneous fat (SF) and cardiovascular disease (CVD) risks are well known, the relation between marrow fat (MF) and metabolic risk is unexplored. Objectives: We examined the relations between these three fat depots and whether CVD risks are associated with marrow adiposity. Design: Observational cross-sectional study. Subjects and methods: Computed tomography was used to measure VF, SF and MF depots in 131 healthy young adults (60 females, 71 males; 16-25 years of age). Weight, body mass index (BMI), waist and hip circumferences, blood pressure (BP), carotid intima-media thickness (CIMT) and serum levels of lipids, glucose and insulin were also measured. Results: Regardless of gender, MF was not associated with values of VF or SF, anthropometric measures, or lipid or carbohydrate serum levels (P>0.05 for all). In contrast, VF was associated with SF (r values=0.74 for females, 0.78 for males; both P-values
ISSN:0307-0565
1476-5497
DOI:10.1038/ijo.2008.170