H3K79 Methylation Profiles Define Murine and Human MLL-AF4 Leukemias

We created a mouse model wherein conditional expression of an Mll-AF4 fusion oncogene induces B precursor acute lymphoblastic (ALL) or acute myeloid leukemias (AML). Gene expression profile analysis of the ALL cells demonstrated significant overlap with human MLL-rearranged ALL. ChIP-chip analysis d...

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Bibliographic Details

Published in:	Cancer cell 2008-11, Vol.14 (5), p.355-368
Main Authors:	Krivtsov, Andrei V., Feng, Zhaohui, Lemieux, Madeleine E., Faber, Joerg, Vempati, Sridhar, Sinha, Amit U., Xia, Xiaobo, Jesneck, Jonathan, Bracken, Adrian P., Silverman, Lewis B., Kutok, Jeffery L., Kung, Andrew L., Armstrong, Scott A.
Format:	Article
Language:	eng
Subjects:	Animals Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Cell Differentiation CELLCYCLE Cells, Cultured Chromatin Immunoprecipitation Female Flow Cytometry Gene Expression Profiling Gene Expression Regulation, Leukemic Gene Rearrangement Histone-Lysine N-Methyltransferase Histones - chemistry Histones - genetics Histones - metabolism Homeodomain Proteins - metabolism Humans Immunophenotyping Integrases - metabolism Leukemia, Myeloid, Acute - genetics Leukemia, Myeloid, Acute - pathology Lysine - chemistry Lysine - genetics Lysine - metabolism Male Methylation Methyltransferases - antagonists & inhibitors Methyltransferases - physiology Mice Mice, Transgenic Myeloid-Lymphoid Leukemia Protein - physiology Oligonucleotide Array Sequence Analysis Oncogene Proteins, Fusion - physiology Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - genetics Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - pathology Principal Component Analysis Protein Methyltransferases - genetics Protein Methyltransferases - metabolism RNA, Small Interfering - pharmacology Transcription, Genetic
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