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Gene expression profiling of liver metastases from colorectal cancer as potential basis for treatment choice
At present no reports on gene expression profiling of liver metastases from colorectal cancer are available. We identified two different signatures using Affymetrix platform: epidermal growth factor receptor pathway was upregulated in metachronous lesions, whereas the pathway mainly related to angio...
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| Published in: | British journal of cancer 2008-11, Vol.99 (10), p.1729-1734 |
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| Main Authors: | , , , , , , , , , , |
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| container_end_page | 1734 |
| container_issue | 10 |
| container_start_page | 1729 |
| container_title | British journal of cancer |
| container_volume | 99 |
| creator | Pantaleo, M A Astolfi, A Nannini, M Paterini, P Piazzi, G Ercolani, G Brandi, G Martinelli, G Pession, A Pinna, A D Biasco, G |
| description | At present no reports on gene expression profiling of liver metastases from colorectal cancer are available. We identified two different signatures using Affymetrix platform: epidermal growth factor receptor pathway was upregulated in metachronous lesions, whereas the pathway mainly related to angiogenesis was in synchronous lesions. Synchronous or metachronous liver metastases could be treated differently on the basis of different molecular pathways. |
| doi_str_mv | 10.1038/sj.bjc.6604681 |
| format | article |
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We identified two different signatures using Affymetrix platform: epidermal growth factor receptor pathway was upregulated in metachronous lesions, whereas the pathway mainly related to angiogenesis was in synchronous lesions. Synchronous or metachronous liver metastases could be treated differently on the basis of different molecular pathways.</description><identifier>ISSN: 0007-0920</identifier><identifier>EISSN: 1532-1827</identifier><identifier>DOI: 10.1038/sj.bjc.6604681</identifier><identifier>PMID: 18827815</identifier><identifier>CODEN: BJCAAI</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Adult ; Aged ; Angiogenesis ; Biological and medical sciences ; Biomarkers, Tumor - genetics ; Biomedical and Life Sciences ; Biomedicine ; Cancer Research ; Cancer therapies ; Colorectal cancer ; Colorectal Neoplasms - genetics ; Colorectal Neoplasms - pathology ; Drug Resistance ; Epidemiology ; Epidermal growth factor ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; Gene expression ; Gene Expression Profiling ; Genetics and Genomics ; Genomics ; Hematology ; Humans ; Liver ; Liver Neoplasms - genetics ; Liver Neoplasms - secondary ; Male ; Medical research ; Medical sciences ; Metastasis ; Middle Aged ; Molecular Medicine ; Neoplasms, Multiple Primary - genetics ; Neoplasms, Second Primary - genetics ; Oncology ; Receptor, Epidermal Growth Factor - genetics ; Software ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Surgery ; Tumors</subject><ispartof>British journal of cancer, 2008-11, Vol.99 (10), p.1729-1734</ispartof><rights>The Author(s) 2008</rights><rights>2009 INIST-CNRS</rights><rights>Copyright Nature Publishing Group Nov 4, 2008</rights><rights>Copyright © 2008 Cancer Research UK 2008 Cancer Research UK</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c538t-c5a22ebe08e94db1804a620bf0609ecce467d369ea4f9799d0662aefc15bb5b33</citedby><cites>FETCH-LOGICAL-c538t-c5a22ebe08e94db1804a620bf0609ecce467d369ea4f9799d0662aefc15bb5b33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2584956/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2584956/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,730,783,787,888,27936,27937,53804,53806</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20977171$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18827815$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pantaleo, M A</creatorcontrib><creatorcontrib>Astolfi, A</creatorcontrib><creatorcontrib>Nannini, M</creatorcontrib><creatorcontrib>Paterini, P</creatorcontrib><creatorcontrib>Piazzi, G</creatorcontrib><creatorcontrib>Ercolani, G</creatorcontrib><creatorcontrib>Brandi, G</creatorcontrib><creatorcontrib>Martinelli, G</creatorcontrib><creatorcontrib>Pession, A</creatorcontrib><creatorcontrib>Pinna, A D</creatorcontrib><creatorcontrib>Biasco, G</creatorcontrib><title>Gene expression profiling of liver metastases from colorectal cancer as potential basis for treatment choice</title><title>British journal of cancer</title><addtitle>Br J Cancer</addtitle><addtitle>Br J Cancer</addtitle><description>At present no reports on gene expression profiling of liver metastases from colorectal cancer are available. We identified two different signatures using Affymetrix platform: epidermal growth factor receptor pathway was upregulated in metachronous lesions, whereas the pathway mainly related to angiogenesis was in synchronous lesions. Synchronous or metachronous liver metastases could be treated differently on the basis of different molecular pathways.</description><subject>Adult</subject><subject>Aged</subject><subject>Angiogenesis</subject><subject>Biological and medical sciences</subject><subject>Biomarkers, Tumor - genetics</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cancer Research</subject><subject>Cancer therapies</subject><subject>Colorectal cancer</subject><subject>Colorectal Neoplasms - genetics</subject><subject>Colorectal Neoplasms - pathology</subject><subject>Drug Resistance</subject><subject>Epidemiology</subject><subject>Epidermal growth factor</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Gene expression</subject><subject>Gene Expression Profiling</subject><subject>Genetics and Genomics</subject><subject>Genomics</subject><subject>Hematology</subject><subject>Humans</subject><subject>Liver</subject><subject>Liver Neoplasms - genetics</subject><subject>Liver Neoplasms - secondary</subject><subject>Male</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Metastasis</subject><subject>Middle Aged</subject><subject>Molecular Medicine</subject><subject>Neoplasms, Multiple Primary - genetics</subject><subject>Neoplasms, Second Primary - genetics</subject><subject>Oncology</subject><subject>Receptor, Epidermal Growth Factor - genetics</subject><subject>Software</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. 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| subjects | Adult Aged Angiogenesis Biological and medical sciences Biomarkers, Tumor - genetics Biomedical and Life Sciences Biomedicine Cancer Research Cancer therapies Colorectal cancer Colorectal Neoplasms - genetics Colorectal Neoplasms - pathology Drug Resistance Epidemiology Epidermal growth factor Female Gastroenterology. Liver. Pancreas. Abdomen Gene expression Gene Expression Profiling Genetics and Genomics Genomics Hematology Humans Liver Liver Neoplasms - genetics Liver Neoplasms - secondary Male Medical research Medical sciences Metastasis Middle Aged Molecular Medicine Neoplasms, Multiple Primary - genetics Neoplasms, Second Primary - genetics Oncology Receptor, Epidermal Growth Factor - genetics Software Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Surgery Tumors |
| title | Gene expression profiling of liver metastases from colorectal cancer as potential basis for treatment choice |
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