Gene expression profiling of liver metastases from colorectal cancer as potential basis for treatment choice

At present no reports on gene expression profiling of liver metastases from colorectal cancer are available. We identified two different signatures using Affymetrix platform: epidermal growth factor receptor pathway was upregulated in metachronous lesions, whereas the pathway mainly related to angio...

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Bibliographic Details
Published in:British journal of cancer 2008-11, Vol.99 (10), p.1729-1734
Main Authors: Pantaleo, M A, Astolfi, A, Nannini, M, Paterini, P, Piazzi, G, Ercolani, G, Brandi, G, Martinelli, G, Pession, A, Pinna, A D, Biasco, G
Format: Article
Language:English
Subjects:
Adult
Aged
Angiogenesis
Biological and medical sciences
Biomarkers, Tumor - genetics
Biomedical and Life Sciences
Biomedicine
Cancer Research
Cancer therapies
Colorectal cancer
Colorectal Neoplasms - genetics
Colorectal Neoplasms - pathology
Drug Resistance
Epidemiology
Epidermal growth factor
Female
Gastroenterology. Liver. Pancreas. Abdomen
Gene expression
Gene Expression Profiling
Genetics and Genomics
Genomics
Hematology
Humans
Liver
Liver Neoplasms - genetics
Liver Neoplasms - secondary
Male
Medical research
Medical sciences
Metastasis
Middle Aged
Molecular Medicine
Neoplasms, Multiple Primary - genetics
Neoplasms, Second Primary - genetics
Oncology
Receptor, Epidermal Growth Factor - genetics
Software
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Surgery
Tumors
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Description
Summary:At present no reports on gene expression profiling of liver metastases from colorectal cancer are available. We identified two different signatures using Affymetrix platform: epidermal growth factor receptor pathway was upregulated in metachronous lesions, whereas the pathway mainly related to angiogenesis was in synchronous lesions. Synchronous or metachronous liver metastases could be treated differently on the basis of different molecular pathways.
ISSN:0007-0920
1532-1827
DOI:10.1038/sj.bjc.6604681