Semaphorin 4D Regulates Gonadotropin Hormone-Releasing Hormone-1 Neuronal Migration through PlexinB1-Met Complex

In mammals, reproduction is dependent on specific neurons secreting the neuropeptide gonadotropin hormone-releasing hormone-1 (GnRH-1). These cells originate during embryonic development in the olfactory placode and migrate into the forebrain, where they become integral members of the hypothalamic-p...

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Bibliographic Details
Published in:The Journal of cell biology 2008-11, Vol.183 (3), p.555-566
Main Authors: Giacobini, Paolo, Messina, Andrea, Morello, Francesca, Ferraris, Nicoletta, Corso, Simona, Penachioni, Junia, Giordano, Silvia, Tamagnone, Luca, Fasolo, Aldo
Format: Article
Language:English
Subjects:
Animals
Antigens, CD - physiology
Axons
Brain
Cell Adhesion
Cell adhesion & migration
Cell aggregates
Cell motility
Cell Movement
Cells
Cercopithecus aethiops
Chemotaxis
COS Cells
Embryo, Mammalian - physiology
Embryos
Female
Gonadotropin-Releasing Hormone - genetics
Gonadotropin-Releasing Hormone - physiology
Hepatocytes
Homeostasis
Hormones
Mammals
Mice
Neurons
Neurons - physiology
Nose - embryology
Peptides
Phosphorylation
Pregnancy
Receptors
Reverse Transcriptase Polymerase Chain Reaction
Semaphorins
Semaphorins - physiology
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Summary:In mammals, reproduction is dependent on specific neurons secreting the neuropeptide gonadotropin hormone-releasing hormone-1 (GnRH-1). These cells originate during embryonic development in the olfactory placode and migrate into the forebrain, where they become integral members of the hypothalamic-pituitary-gonadal axis. This migratory process is regulated by a wide range of guidance cues, which allow GnRH-1 cells to travel over long distances to reach their appropriate destinations. The Sema-phorin4D (Sema4D) receptor, PlexinB1, is highly expressed in the developing olfactory placode, but its function in this context is still unknown. Here, we demonstrate that PlexinB1-deficient mice exhibit a migratory defect of GnRH-1 neurons, resulting in reduction of this cell population in the adult brain. Moreover, Sema4D promotes directional migration in GnRH-1 cells by coupling PlexinB1 with activation of the Met tyrosine kinase (hepatocyte growth factor receptor). This work identifies a function for PlexinB1 during brain development and provides evidence that Sema4D controls migration of GnRH-1 neurons.
ISSN:0021-9525
1540-8140
DOI:10.1083/jcb.200806160