Hemorrhagic Fever with Renal Syndrome Caused by 2 Lineages of Dobrava Hantavirus, Russia1

These lineages, including a new lineage associated with the novel rodent host Apodemus ponticus , are emerging. Dobrava-Belgrade virus (DOBV) is a European hantavirus that causes hemorrhagic fever with renal syndrome (HFRS); case-fatality rates in Balkan countries are as high as 12%. To determine ca...

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Bibliographic Details
Published in:Emerging infectious diseases 2008-04, Vol.14 (4), p.617-625
Main Authors: Klempa, Boris, Tkachenko, Evgeniy A., Dzagurova, Tamara K., Yunicheva, Yulia V., Morozov, Vyacheslav G., Okulova, Natalia M., Slyusareva, Galina P., Smirnov, Aleksey, Kruger, Detlev H.
Format: Article
Language:English
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Summary:These lineages, including a new lineage associated with the novel rodent host Apodemus ponticus , are emerging. Dobrava-Belgrade virus (DOBV) is a European hantavirus that causes hemorrhagic fever with renal syndrome (HFRS); case-fatality rates in Balkan countries are as high as 12%. To determine causative agents, we examined 126 cases of DOBV-associated HFRS in central and southern European Russia. In central Russia (Lipetsk, Voronezh, Orel regions), outbreaks were caused by a DOBV variant (DOBV-Aa) carried by Apodemus agrarius . In southern Russia (Sochi district), where HFRS is endemic, HFRS cases were caused by a new DOBV variant (DOBV-Ap), found in A. ponticus, a novel hantavirus natural host. Both viruses, DOBV-Aa/Lipetsk and DOBV-Ap/Sochi, were isolated through Vero E6 cells, genetically characterized, and used for serotyping of the HFRS patients’ serum. The clinical severity of HFRS caused by DOBV-Aa resembles that of HFRS caused by Puumala virus (mild to moderate); clinical severity of disease caused by DOBV-Ap infections is more often moderate to severe.
ISSN:1080-6040
1080-6059
DOI:10.3201/eid1404.071310