Recurrent wheezing in very preterm infants

AIMS: To document the prevalence of, and identify risk factors for, recurrent wheezing treated with bronchodilators in the first year of life. METHODS: Parental history and neonatal data were collected prospectively in a regional cohort of very preterm infants (< 33 weeks). Data on maternal smoki...

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Bibliographic Details
Published in:Archives of disease in childhood. Fetal and neonatal edition 1996-05, Vol.74 (3), p.F165-F171
Main Authors: Elder, D. E., Hagan, R., Evans, S. F., Benninger, H. R., French, N. P.
Format: Article
Language:English
Subjects:
Bronchial Hyperreactivity
Bronchodilator Agents - therapeutic use
Cohort Studies
Family Characteristics
Female
Gestational Age
Humans
Incidence
Infant
Infant, Newborn
Infant, Premature
Logistic Models
Male
Maternal Exposure
Oxygen Inhalation Therapy
Prospective Studies
Respiratory Sounds
Risk Factors
Smoking
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Summary:AIMS: To document the prevalence of, and identify risk factors for, recurrent wheezing treated with bronchodilators in the first year of life. METHODS: Parental history and neonatal data were collected prospectively in a regional cohort of very preterm infants (< 33 weeks). Data on maternal smoking, siblings at home, breast feeding, respiratory symptoms, and hospital re-admissions were documented at 12 months. RESULTS: Outcome data were available for 525/560 (95%) of survivors. The incidence of recurrent wheeze was 76/525 (14.5%) in very preterm infants and 20/657 (3%) in a cohort of term newborns. Significant risk factors for recurrent wheeze in very preterm infants were parental history of asthma, maternal smoking, siblings at home, neonatal oxygen supplementation at 28 days, 36, and 40 weeks of gestation. CONCLUSIONS: Wheezing respiratory illnesses are common in very preterm infants. The factors involved are similar to those in more mature infants, with the addition of immaturity and neonatal lung injury.
ISSN:1359-2998
1468-2052
DOI:10.1136/fn.74.3.F165