Increased EEG gamma band activity in Alzheimer’s disease and mild cognitive impairment

High frequency (30–70 Hz) gamma band oscillations in the human electro-encephalogram (EEG) are thought to reflect perceptual and cognitive processes. It is therefore interesting to study these measures in cognitive impairment and dementia. To evaluate gamma band oscillations as a diagnostic biomarke...

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Bibliographic Details
Published in:Journal of Neural Transmission 2008-09, Vol.115 (9), p.1301-1311
Main Authors: van Deursen, J. A., Vuurman, E. F. P. M., Verhey, F. R. J., van Kranen-Mastenbroek, V. H. J. M., Riedel, W. J.
Format: Article
Language:English
Subjects:
Acoustic Stimulation
Action Potentials - physiology
Aged
Aged, 80 and over
Alzheimer Disease - diagnosis
Alzheimer Disease - physiopathology
Alzheimer's Disease and Related Disorders - Original
Alzheimer's Disease and Related Disorders - Original Article
Auditory Perception - physiology
Biomarkers
Cerebral Cortex - physiopathology
Cognition Disorders - diagnosis
Cognition Disorders - physiopathology
Disability Evaluation
Electroencephalography - methods
Electromyography
Evoked Potentials - physiology
Female
Humans
Male
Medicine
Medicine & Public Health
Middle Aged
Nerve Net - physiopathology
Neurology
Neurons - physiology
Neuropsychological Tests
Neurosciences
Predictive Value of Tests
Psychiatry
Reproducibility of Results
Up-Regulation - physiology
Visual Perception - physiology
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Summary:High frequency (30–70 Hz) gamma band oscillations in the human electro-encephalogram (EEG) are thought to reflect perceptual and cognitive processes. It is therefore interesting to study these measures in cognitive impairment and dementia. To evaluate gamma band oscillations as a diagnostic biomarker in Alzheimer’s disease (AD) and mild cognitive impairment (MCI), 15 psychoactive drug naïve AD patients, 20 MCI patients and 20 healthy controls participated in this study. Gamma band power (GBP) was measured in four conditions viz. resting state, music listening, story listening and visual stimulation. To evaluate test–retest reliability (TRR), subjects underwent a similar assessment one week after the first. The overall TRR was high. Elevated GBP was observed in AD when compared to MCI and control subjects in all conditions. The results suggest that elevated GBP is a reproducible and sensitive measure for cognitive dysfunction in AD in comparison with MCI and controls.
ISSN:0300-9564
1435-1463
DOI:10.1007/s00702-008-0083-y