Health related quality of life after combined hormone replacement therapy: randomised controlled trial

Objective To assess the effect of combined hormone replacement therapy (HRT) on health related quality of life.Design Randomised placebo controlled double blind trial.Setting General practices in United Kingdom (384), Australia (94), and New Zealand (24).Participants Postmenopausal women aged 50-69...

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Bibliographic Details
Published in:	BMJ 2008-09, Vol.337 (7669), p.550-553
Main Authors:	Welton, Amanda J, Vickers, Madge R, Kim, Joseph, Ford, Deborah, Lawton, Beverley A, MacLennan, Alastair H, Meredith, Sarah K, Martin, Jeannett, Meade, Tom W
Format:	Article
Language:	eng
Subjects:	Aged Biological and medical sciences Clinical trials Double-Blind Method Drug Therapy, Combination Estrogens Estrogens - administration & dosage Experimentation Female General aspects Health Status Hormone replacement therapy Hormone Replacement Therapy - methods Humans Hysterectomy Medical sciences Menopause Middle Aged Placebos Postmenopause Postmenopause - psychology Progestins - administration & dosage Prognosis Quality of Life Questionnaires Studies Surveys and Questionnaires Wisdom Women Women's Health Women's issues Womens health
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Summary:	Objective To assess the effect of combined hormone replacement therapy (HRT) on health related quality of life.Design Randomised placebo controlled double blind trial.Setting General practices in United Kingdom (384), Australia (94), and New Zealand (24).Participants Postmenopausal women aged 50-69 at randomisation; 3721 women with a uterus were randomised to combined oestrogen and progestogen (n=1862) or placebo (n=1859). Data on health related quality of life at one year were available from 1043 and 1087 women, respectively.Interventions Conjugated equine oestrogen 0.625 mg plus medroxyprogesterone acetate 2.5/5.0 mg or matched placebo orally daily for one year.Main outcome measures Health related quality of life and psychological wellbeing as measured by the women’s health questionnaire. Changes in emotional and physical menopausal symptoms as measured by a symptoms questionnaire and depression by the Centre for Epidemiological Studies depression scale (CES-D). Overall health related quality of life and overall quality of life as measured by the European quality of life instrument (EuroQol) and visual analogue scale, respectively.Results After one year small but significant improvements were observed in three of nine components of the women’s health questionnaire for those taking combined HRT compared with those taking placebo: vasomotor symptoms (P
ISSN:	0959-8138 0959-8146 0959-535X 1468-5833 1756-1833