Resectability of advanced liver tumours in children after combination chemotherapy

Five patients with locally advanced or metastatic liver tumours were treated at the Royal Hospital for Sick Children between 1983 and 1992 by preoperative combination chemotherapy and subsequent complete resection of the residual liver tumour. Chemotherapy was generally well tolerated with few signi...

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Bibliographic Details
Published in:Annals of the Royal College of Surgeons of England 1994-07, Vol.76 (4), p.253-256
Main Authors: Munro, F D, Simpson, E, Azmy, A F
Format: Article
Language:English
Subjects:
Antineoplastic Agents - therapeutic use
Child
Cisplatin - administration & dosage
Combined Modality Therapy
Doxorubicin - administration & dosage
Female
Hepatoblastoma - diagnostic imaging
Hepatoblastoma - drug therapy
Hepatoblastoma - pathology
Hepatoblastoma - surgery
Humans
Infant
Liver Neoplasms - diagnostic imaging
Liver Neoplasms - drug therapy
Liver Neoplasms - pathology
Liver Neoplasms - surgery
Tomography, X-Ray Computed
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Summary:Five patients with locally advanced or metastatic liver tumours were treated at the Royal Hospital for Sick Children between 1983 and 1992 by preoperative combination chemotherapy and subsequent complete resection of the residual liver tumour. Chemotherapy was generally well tolerated with few significant adverse effects. Tumour resection was accomplished by lobectomy in three cases and an extended lobectomy in the remaining two. All five children are currently well and free of disease at a mean follow-up of 36 months.
ISSN:0035-8843
1478-7083