Regulation of phosphate homeostasis by the phosphatonins and other novel mediators

A variety of factors regulate the efficiency of phosphate absorption in the intestine and phosphate reabsorption in kidney. Apart from the well-known regulators of phosphate homeostasis, namely parathyroid hormone (PTH) and the vitamin D–endocrine system, a number of peptides collectively known as t...

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Bibliographic Details
Published in:Pediatric nephrology (Berlin, West) West), 2008-08, Vol.23 (8), p.1203-1210
Main Authors: Shaikh, Aisha, Berndt, Theresa, Kumar, Rajiv
Format: Article
Language:English
Subjects:
Animals
Child
Fibroblast Growth Factors - metabolism
Fibroblasts
Growth factors
Homeostasis
Homeostasis - physiology
Humans
Hypophosphatemia - metabolism
Medicine & Public Health
Metabolism
Nephrology
Parathyroid Hormone - metabolism
Pathogenesis
Pathophysiology
Pediatrics
Peptides
Phosphates - metabolism
Phosphorus
Physiology
Plasma
Proteins
Review
Rickets
Urology
Vitamin D
Vitamin D - metabolism
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Summary:A variety of factors regulate the efficiency of phosphate absorption in the intestine and phosphate reabsorption in kidney. Apart from the well-known regulators of phosphate homeostasis, namely parathyroid hormone (PTH) and the vitamin D–endocrine system, a number of peptides collectively known as the “phosphatonins” have been recently identified as a result of the study of various diseases associated with hypophosphatemia. These factors, fibroblast growth factor 23 (FGF-23), secreted frizzled-related protein 4 (sFRP-4), fibroblast growth factor 7 (FGF-7) and matrix extracellular phosphoglycoprotein (MEPE), have been shown to play a role in the pathogenesis of various hypophosphatemic and hyperphosphatemic disorders, such as oncogenic osteomalacia, X-linked hypophosphatemic rickets, autosomal dominant hypophosphatemic rickets, autosomal recessive hypophosphatemia and tumoral calcinosis. Whether these factors are true hormones, in the sense that they are regulated by the intake of dietary phosphorus and the needs of the organism for higher or lower amounts of phosphorus, remains to be firmly established in humans. Additionally, new information demonstrates that the intestine “senses” luminal concentrations of phosphate and regulates the excretion of phosphate in the kidney by elaborating novel factors that alter renal phosphate reabsorption.
ISSN:0931-041X
1432-198X
DOI:10.1007/s00467-008-0751-z