Micro- and nanotechnology in cell separation

This review describes recent work in cell separation using micro- and nanoscale technologies. These devices offer several advantages over conventional, macroscale separation systems in terms of sample volumes, low cost, portability, and potential for integration with other analytical techniques. Mor...

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Bibliographic Details
Published in:International journal of nanomedicine 2006-01, Vol.1 (1), p.3-14
Main Authors: Radisic, Milica, Iyer, Rohin K, Murthy, Shashi K
Format: Article
Language:English
Subjects:
Cell Separation - instrumentation
Cell Separation - methods
Cell Separation - trends
Flow Cytometry - instrumentation
Flow Cytometry - methods
Flow Cytometry - trends
Lab-On-A-Chip Devices
Microchip Analytical Procedures - methods
Microchip Analytical Procedures - trends
Microfluidic Analytical Techniques - instrumentation
Microfluidic Analytical Techniques - methods
Microfluidic Analytical Techniques - trends
Nanotechnology - instrumentation
Nanotechnology - methods
Nanotechnology - trends
Review
Technology Assessment, Biomedical
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Summary:This review describes recent work in cell separation using micro- and nanoscale technologies. These devices offer several advantages over conventional, macroscale separation systems in terms of sample volumes, low cost, portability, and potential for integration with other analytical techniques. More importantly, and in the context of modern medicine, these technologies provide tools for point-of-care diagnostics, drug discovery, and chemical or biological agent detection. This review describes work in five broad categories of cell separation based on (1) size, (2) magnetic attraction, (3) fluorescence, (4) adhesion to surfaces, and (5) new emerging technologies. The examples in each category were selected to illustrate separation principles and technical solutions as well as challenges facing this rapidly emerging field.
ISSN:1176-9114
1178-2013
DOI:10.2147/nano.2006.1.1.3