Effect of Helicobacter pylori eradication on peptic ulcer healing

In a prospective study designed to assess the effect of Helicobacter pylori eradication on peptic ulcer healing, 85 consecutive patients with H. pylori-positive peptic ulcer disease were treated with a triple therapy regimen consisting of colloidal bismuth subcitrate 120 mg four times daily for 28 d...

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Bibliographic Details
Published in:Postgraduate medical journal 1995-02, Vol.71 (832), p.90-93
Main Authors: O'Connor, H. J., Kanduru, C., Bhutta, A. S., Meehan, J. M., Feeley, K. M., Cunnane, K.
Format: Article
Language:English
Subjects:
Adult
Aged
Drug Therapy, Combination
Duodenal Ulcer - microbiology
Duodenal Ulcer - therapy
Female
Helicobacter Infections - drug therapy
Helicobacter pylori - drug effects
Humans
Male
Metronidazole - therapeutic use
Middle Aged
Organometallic Compounds - therapeutic use
Peptic Ulcer - therapy
Prospective Studies
Smoking
Stomach Ulcer - microbiology
Stomach Ulcer - therapy
Tetracycline - therapeutic use
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Summary:In a prospective study designed to assess the effect of Helicobacter pylori eradication on peptic ulcer healing, 85 consecutive patients with H. pylori-positive peptic ulcer disease were treated with a triple therapy regimen consisting of colloidal bismuth subcitrate 120 mg four times daily for 28 days, with metronidazole 400 mg three times daily and tetracycline 500 mg three times daily for the first seven days of treatment. H. pylori status was assessed by CLO test and histology at least four weeks after completing therapy. Of 75 patients (88%) H. pylori-negative after therapy, 69 (92%) had healed ulcers compared with only five of 10 patients (50%) who remained H. pylori-positive (p = 0.003). Cigarette smoking had no significant effect on ulcer healing. Our results suggest that H. pylori eradication may accelerate ulcer healing and provide further evidence that an effective helicobactericidal regimen is the treatment of choice in H. pylori-positive peptic ulcer.
ISSN:0032-5473
1469-0756
DOI:10.1136/pgmj.71.832.90