Human kallikrein gene 13 (KLK13) expression by quantitative RT-PCR: an independent indicator of favourable prognosis in breast cancer

Kallikreins are a group of serine proteases with diverse physiological functions. KLK13 (previously known as KLK-L4) is a novel kallikrein gene located on chromosome 19q13.4 and shares a high degree of homology with other kallikrein family members. Many kallikrein genes were found to be differential...

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Bibliographic Details
Published in:British journal of cancer 2002-05, Vol.86 (9), p.1457-1464
Main Authors: CHANG, A, YOUSEF, G. M, SCORILAS, A, GRASS, L, SISMONDI, P, PONZONE, R, DIAMANDIS, E. P
Format: Article
Language:English
Subjects:
Adult
Aged
Biological and medical sciences
Breast cancer
Breast Neoplasms - genetics
Breast Neoplasms - pathology
Cancer research
Cancer therapies
Carcinoma - genetics
Carcinoma - pathology
Female
Gene Expression Regulation, Neoplastic
Growth factors
Gynecology. Andrology. Obstetrics
Humans
Kallikreins - analysis
Kallikreins - biosynthesis
Mammary gland diseases
Medical prognosis
Medical research
Medical sciences
Metastasis
Middle Aged
Molecular and Cellular Pathology
Neoplasm Recurrence, Local
Ovarian cancer
Polymerase chain reaction
Prognosis
Prostate cancer
Receptors, Estrogen - analysis
Receptors, Progesterone - analysis
Reverse Transcriptase Polymerase Chain Reaction
Risk Factors
Steroids
Survival Analysis
Tumors
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Summary:Kallikreins are a group of serine proteases with diverse physiological functions. KLK13 (previously known as KLK-L4) is a novel kallikrein gene located on chromosome 19q13.4 and shares a high degree of homology with other kallikrein family members. Many kallikrein genes were found to be differentially expressed in various malignancies, and their regulation is controlled by steroid hormones in prostate and breast cancer cell lines. We studied the expression of KLK13 by quantitative reverse transcriptase-polymerase chain reaction in 173 patients with epithelial breast carcinoma. An optimal cutoff point equal to the 40th percentile was defined, based on the ability of KLK13 to predict disease-free survival. KLK13 values were then associated with other established prognostic factors and with disease-free survival and overall survival. Higher positivity for KLK13 expression was found in older, oestrogen receptor positive patients. In univariate analysis, KLK13 expression is a significant predictor of improved disease-free survival and overall survival (P
ISSN:0007-0920
1532-1827
DOI:10.1038/sj.bjc.6600283