Does place of birth influence endogenous hormone levels in Asian-American women?

In 1983-87, we conducted a population-based case-control study of breast cancer in Asian women living in California and Hawaii, in which migration history (a composite of the subject's place of birth, usual residence in Asia (urban/rural), length of time living in the West, and grandparents...

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Bibliographic Details
Published in:British journal of cancer 2002-07, Vol.87 (1), p.54-60
Main Authors: FALK, R. T, FEARS, T. R, HOOVER, R. N, PIKE, M. C, WU, A. H, NOMURA, A. M. Y, KOLONEL, L. N, WEST, D. W, ZIEGLER, R. G
Format: Article
Language:English
Subjects:
Adult
Androgens
Asia - ethnology
Asian Americans
Biological and medical sciences
Breast cancer
Breast Neoplasms - epidemiology
Breast Neoplasms - ethnology
Breast Neoplasms - etiology
Cancer research
Case-Control Studies
Emigration and Immigration
Epidemiology
Female
Geography
Gonadal Steroid Hormones - analysis
Gonadal Steroid Hormones - genetics
Gynecology. Andrology. Obstetrics
Hormones
Humans
Incidence
Mammary gland diseases
Medical research
Medical sciences
Middle Aged
Migration
Pedigree
Postmenopause
Premenopause
Risk Assessment
Rural areas
Scandals
Tumors
United States - epidemiology
White people
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Summary:In 1983-87, we conducted a population-based case-control study of breast cancer in Asian women living in California and Hawaii, in which migration history (a composite of the subject's place of birth, usual residence in Asia (urban/rural), length of time living in the West, and grandparents' place of birth) was associated with a six-fold risk gradient that paralleled the historical differences in incidence rates between the US and Asian countries. This provided the opportunity to determine whether endogenous hormones vary with migration history in Asian-American women. Plasma obtained from 316 premenopausal and 177 naturally premenopausal study controls was measured for levels of estrone (E1), estradiol (E2), estrone sulphate (E1S), androstenedione (A), testosterone (T), dehydroepiandrosterone (DHEA), dehydroepiandrosterone sulphate (DHEAS), progesterone (PROG) and sex hormone-binding globulin (SHBG). Levels of the oestrogens and sex hormone-binding globulin did not differ significantly between Asian- and Western-born women, although among premenopausal women, those least westernised had the lowest levels of E1, E2, and E1S. Androgen levels, particularly DHEA, were lower in women born in the West. Among premenopausal women, age-adjusted geometric mean levels of DHEA were 16.5 and 13.8 nmol l(-1) in Asian- and Western-born women respectively; in postmenopausal women these values were 11.8 and 9.2 nmol l(-1), (P
ISSN:0007-0920
1532-1827
DOI:10.1038/sj.bjc.6600339