The expression of thymidine phosphorylase correlates with angiogenesis and the efficacy of chemotherapy using fluorouracil derivatives in advanced gastric carcinoma

The expression of thymidine phosphorylase (TP) and the density of microvessel in advanced gastric carcinoma were examined by immunohistochemistry to evaluate the significance of TP. The expression of TP was negative in 72 cases, positive in 54. The microvessel density correlated with the expression...

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Bibliographic Details
Published in:British Journal of Cancer 1999-10, Vol.81 (3), p.484-489
Main Authors: SAITO, H, TSUJITANI, S, OKA, S, KONDO, A, IKEGUCHI, M, MAETA, M, KAIBARA, N
Format: Article
Language:English
Subjects:
Adenocarcinoma - blood supply
Adenocarcinoma - drug therapy
Adenocarcinoma - enzymology
Adenocarcinoma - pathology
Adenocarcinoma - surgery
Adult
Aged
Aged, 80 and over
Antineoplastic agents
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Biological and medical sciences
Biomarkers, Tumor - biosynthesis
Biomarkers, Tumor - genetics
Capillaries - pathology
Chemotherapy
Combined Modality Therapy
Enzyme Induction
Female
Fluorouracil - administration & dosage
Gastrectomy
Gastric Mucosa - enzymology
Humans
Japan - epidemiology
Lymphatic Metastasis
Male
Medical sciences
Middle Aged
Neoplasm Invasiveness
Neoplasm Proteins - biosynthesis
Neoplasm Proteins - genetics
Neovascularization, Pathologic - enzymology
Neovascularization, Pathologic - genetics
Pharmacology. Drug treatments
Prognosis
Proportional Hazards Models
Regular
Stomach Neoplasms - blood supply
Stomach Neoplasms - drug therapy
Stomach Neoplasms - enzymology
Stomach Neoplasms - pathology
Stomach Neoplasms - surgery
Thymidine Phosphorylase - biosynthesis
Thymidine Phosphorylase - genetics
Treatment Outcome
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Summary:The expression of thymidine phosphorylase (TP) and the density of microvessel in advanced gastric carcinoma were examined by immunohistochemistry to evaluate the significance of TP. The expression of TP was negative in 72 cases, positive in 54. The microvessel density correlated with the expression of TP. In total cases, patients with TP-positive tumours survived longer than those with TP-negative tumours. In patients treated with fluorouracil derivatives (FUs), the expression of TP significantly correlated with favourable prognosis and with unfavourable prognosis in those not treated with FUs. The patients with TP-positive tumours, the prognosis of patients treated with FUs was significantly better than that of those not treated with FUs. In patients with TP-positive tumours, treatment with FUs and lymph node metastasis were independent prognostic factors according to the Cox proportional hazards model. Depth of invasion and lymph node metastasis were independent prognostic factors in patients with TP-negative tumours. The determination of the expression of TP might be useful for predicting the efficacy of post-operative chemotherapy using FUs to prevent recurrence in advanced gastric carcinoma patients who undergo curative gastrectomy.
ISSN:0007-0920
1476-5381
1532-1827
DOI:10.1038/sj.bjc.6690719