Circulating cell-free DNA as a predictive marker for distant metastasis of hepatitis C virus-related hepatocellular carcinoma

In a previous study, we showed that levels of cell-free DNA (cfDNA) were significantly higher in sera of patients with hepatocellular carcinoma (HCC) associated with hepatitis C virus (HCV) than in sera of non-HCC patients with HCV. To confirm this finding, we analysed serum cfDNA levels in a cohort...

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Bibliographic Details
Published in:British journal of cancer 2007-11, Vol.97 (10), p.1399-1403
Main Authors: TOKUHISA, Y, IIZUKA, N, SAKAMOTO, K, TAMESA, T, OKA, M, SAKAIDA, I, MORIBE, T, FUJITA, N, MIURA, T, TAMATSUKURI, S, ISHITSUKA, H, UCHIDA, K, TERAI, S
Format: Article
Language:English
Subjects:
Aged
Biological and medical sciences
Biomarkers
Biomarkers, Tumor - blood
Cancer research
Carcinoma, Hepatocellular - blood
Carcinoma, Hepatocellular - secondary
Carcinoma, Hepatocellular - virology
DNA, Neoplasm - blood
Female
Follow-Up Studies
Gastroenterology. Liver. Pancreas. Abdomen
Hepacivirus - isolation & purification
Hepatectomy
Hepatitis B
Hepatitis C
Hepatitis C - blood
Hepatitis C - complications
Hepatitis C virus
Humans
Liver cancer
Liver Neoplasms - blood
Liver Neoplasms - secondary
Liver Neoplasms - virology
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Male
Medical prognosis
Medical research
Medical sciences
Medicine
Metastasis
Middle Aged
Molecular Diagnostics
Patients
Predictive Value of Tests
Proportional Hazards Models
Recurrence
Survival Rate
Tumors
University graduates
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Summary:In a previous study, we showed that levels of cell-free DNA (cfDNA) were significantly higher in sera of patients with hepatocellular carcinoma (HCC) associated with hepatitis C virus (HCV) than in sera of non-HCC patients with HCV. To confirm this finding, we analysed serum cfDNA levels in a cohort of 96 patients with HCV-related HCC and in 100 HCV carriers without known HCC. Again we found that serum cfDNA levels were significantly higher in HCC patients than in HCV carriers (115.9+/-98.3 vs 34.4+/-40.4 ng ml(-1) (mean+/-s.d.), P
ISSN:0007-0920
1532-1827
DOI:10.1038/sj.bjc.6604034