A simple and reproducible scoring system for EGFR in colorectal cancer: application to prognosis and prediction of response to preoperative brachytherapy

The aim of this study was to determine the predictive and prognostic value of epidermal growth factor receptor (EGFR) expression in rectal cancers treated with preoperative high-dose rate brachytherapy and in mismatch-repair (MMR)-proficient colorectal cancers (CRCs), respectively. We validate the u...

Full description

Saved in:
Bibliographic Details
Published in:British journal of cancer 2007-03, Vol.96 (5), p.793-800
Main Authors: ZLOBEC, I, VUONG, T, HAYASHI, S, HAEGERT, D, TORNILLO, L, TERRACCIANO, L, LUGLI, A, JASS, J
Format: Article
Language:English
Subjects:
Adenocarcinoma - metabolism
Adenocarcinoma - pathology
Adenocarcinoma - radiotherapy
Biological and medical sciences
Biomarkers, Tumor - analysis
Brachytherapy
Colorectal Neoplasms - metabolism
Colorectal Neoplasms - pathology
Colorectal Neoplasms - radiotherapy
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Immunohistochemistry
Medical sciences
Molecular Diagnostics
Neoadjuvant Therapy
Predictive Value of Tests
Prognosis
Receptor, Epidermal Growth Factor - metabolism
Reproducibility of Results
ROC Curve
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Tissue Array Analysis
Treatment Outcome
Tumors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The aim of this study was to determine the predictive and prognostic value of epidermal growth factor receptor (EGFR) expression in rectal cancers treated with preoperative high-dose rate brachytherapy and in mismatch-repair (MMR)-proficient colorectal cancers (CRCs), respectively. We validate the use of receiver operating characteristic (ROC) curve analysis to select cutoff scores for EGFR overexpression for the end points studied. Immunohistochemistry (IHC) for EGFR was performed on 82 rectal tumour biopsies and 1197 MMR-proficient CRCs using a tissue microarray. Immunoreactivity was scored as the percentage of positive tumour cells by three pathologists and the inter-observer reliability was assessed. ROC curve-derived cutoffs were used to analyse the association of EGFR overexpression, tumour response and several clinicopathological features including survival. The scoring method was found to be reproducible in rectal cancer biopsies and CRCs. The selected cutoff scores from ROC curve analysis for each clinicopathological feature were highly consistent among pathologists. EGFR overexpression was associated with response to radiotherapy (P-value
ISSN:0007-0920
1532-1827
DOI:10.1038/sj.bjc.6603619