In Vitro Performance Testing of the Novel Medspray® Wet Aerosol Inhaler Based on the Principle of Rayleigh Break-up

Purpose A new inhaler (Medspray®) for pulmonary drug delivery based on the principle of Rayleigh break-up has been tested with three different spray nozzles (1.5; 2.0 and 2.5 μm) using aqueous 0.1% (w/w) salbutamol and 0.9% (w/w) sodium chloride solutions. Materials and methods Particle size distrib...

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Bibliographic Details
Published in:Pharmaceutical research 2008-05, Vol.25 (5), p.1186-1192
Main Authors: de Boer, Anne H., Wissink, Jeroen, Hagedoorn, Paul, Heskamp, Iwan, de Kruijf, Wilbur, Bünder, Ralf, Zanen, Pieter, Munnik, Paul, van Rijn, Cees, Frijlink, Henderik W.
Format: Article
Language:English
Subjects:
Aerodynamics
Aerosols
Albuterol - chemistry
Biochemistry
Biological and medical sciences
Biomedical and Life Sciences
Biomedical Engineering and Bioengineering
Biomedicine
Diffraction
Fluid dynamics
General pharmacology
Lasers
Medical Law
Medical sciences
Microscopy, Electron, Scanning
Nebulizers and Vaporizers
Particle Size
Pharmaceutical technology. Pharmaceutical industry
Pharmacology
Pharmacology. Drug treatments
Pharmacology/Toxicology
Pharmacy
Research Paper
Respiratory therapy
Sodium Chloride
Solutions
Theory
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Summary:Purpose A new inhaler (Medspray®) for pulmonary drug delivery based on the principle of Rayleigh break-up has been tested with three different spray nozzles (1.5; 2.0 and 2.5 μm) using aqueous 0.1% (w/w) salbutamol and 0.9% (w/w) sodium chloride solutions. Materials and methods Particle size distributions in the aerosol were measured with the principles of time of flight (APS) and laser diffraction (LDA). Results The Medspray® inhaler exhibits a highly constant droplet size distribution in the aerosol during dose emission. Droplets on the basis of Rayleigh break-up theory are monodisperse, but due to some coalescence the aerosols from the Medspray® inhaler are slightly polydisperse. Mass median aerodynamic diameters at 60 l.min −1 from APS are 1.42; 1.32 and 1.27 times the theoretical droplet diameters (TD’s) and median laser diffraction diameters are 1.29; 1.14 and 1.05 times TD for 1.5; 2.0 and 2.5 μm nozzles (TD: 2.84; 3.78 and 4.73 μm respectively). Conclusions The narrow particle size distribution in the aerosol from the Medspray® is highly reproducible for the range of flow rates from 30 to 60 l.min −1 . The mass median aerodynamic droplet diameter can be well controlled within the size range from 4 to 6 μm at 60 l.min −1 .
ISSN:0724-8741
1573-904X
DOI:10.1007/s11095-007-9503-1