Biomimetic materials for tissue engineering

Tissue engineering and regenerative medicine is an exciting research area that aims at regenerative alternatives to harvested tissues for transplantation. Biomaterials play a pivotal role as scaffolds to provide three-dimensional templates and synthetic extracellular matrix environments for tissue r...

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Bibliographic Details
Published in:Advanced drug delivery reviews 2008-01, Vol.60 (2), p.184-198
Main Author: Ma, Peter X.
Format: Article
Language:English
Subjects:
Animals
Biocompatible Materials - chemical synthesis
Biocompatible Materials - chemistry
Biomaterial
Biomimetic
Coated Materials, Biocompatible - chemical synthesis
Coated Materials, Biocompatible - chemistry
Controlled release
Delayed-Action Preparations - chemical synthesis
Delayed-Action Preparations - chemistry
Humans
Matrix
Nano
Nanocomposites - chemistry
Nanostructures - chemistry
Polymer scaffold
Regeneration
Tissue engineering
Tissue Engineering - methods
Tissue Scaffolds - chemistry
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Summary:Tissue engineering and regenerative medicine is an exciting research area that aims at regenerative alternatives to harvested tissues for transplantation. Biomaterials play a pivotal role as scaffolds to provide three-dimensional templates and synthetic extracellular matrix environments for tissue regeneration. It is often beneficial for the scaffolds to mimic certain advantageous characteristics of the natural extracellular matrix, or developmental or wound healing programs. This article reviews current biomimetic materials approaches in tissue engineering. These include synthesis to achieve certain compositions or properties similar to those of the extracellular matrix, novel processing technologies to achieve structural features mimicking the extracellular matrix on various levels, approaches to emulate cell–extracellular matrix interactions, and biologic delivery strategies to recapitulate a signaling cascade or developmental/wound healing program. The article also provides examples of enhanced cellular/tissue functions and regenerative outcomes, demonstrating the excitement and significance of the biomimetic materials for tissue engineering and regeneration.
ISSN:0169-409X
1872-8294
DOI:10.1016/j.addr.2007.08.041