The action of serotonin on calcium-45 efflux from the anterior byssal retractor muscle of Mytilus edulis

(45)Ca efflux was studied in resting anterior byssal retractor muscle. The data are described by a three-compartment system. The most rapidly exchanging compartment, with an average time constant of 7 min, contains about 0.9 mM Ca/liter muscle, and probably represents extracellular space. A second c...

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Bibliographic Details
Published in:The Journal of general physiology 1972-04, Vol.59 (4), p.476-485
Main Authors: Bloomquist, E, Curtis, B A
Format: Article
Language:English
Subjects:
Animals
Calcium - metabolism
Calcium Isotopes
Cell Membrane - metabolism
Extracellular Space - metabolism
In Vitro Techniques
Kinetics
Models, Biological
Muscles - drug effects
Muscles - metabolism
Sarcoplasmic Reticulum - metabolism
Serotonin - pharmacology
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Summary:(45)Ca efflux was studied in resting anterior byssal retractor muscle. The data are described by a three-compartment system. The most rapidly exchanging compartment, with an average time constant of 7 min, contains about 0.9 mM Ca/liter muscle, and probably represents extracellular space. A second compartment, with a time constant of 83 +/- 5 min, contains 1.2 mM Ca/liter, and may represent a membrane calcium store. The presence of a third, or more, compartments, probably representing sarcoplasmic reticulum and contractile proteins, is indicated by the fact that the final time constant is 10 times the 83 min time constant of the second compartment. Serotonin (5HT), on initial application, increases (45)Ca efflux from this third compartment(s). This effect has a typical dose-response relationship with a maximum response appearing at 10(-7)M5HT. In addition, removal of 5HT causes a secondary increase in (45)Ca efflux which has a maximum at a 5HT concentration of 10(-7)M and declines at both higher and lower doses.
ISSN:0022-1295
1540-7748
DOI:10.1085/jgp.59.4.476