Cancer prevention with freeze-dried berries and berry components

Abstract Our laboratory is developing a food-based approach to the prevention of esophageal and colon cancer utilizing freeze-dried berries and berry extracts. Dietary freeze-dried berries were shown to inhibit chemically induced cancer of the rodent esophagus by 30–60% and of the colon by up to 80%...

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Bibliographic Details
Published in:Seminars in cancer biology 2007-10, Vol.17 (5), p.403-410
Main Authors: Stoner, Gary D, Wang, Li-Shu, Zikri, Nancy, Chen, Tong, Hecht, Stephen S, Huang, Chuanshu, Sardo, Christine, Lechner, John F
Format: Article
Language:English
Subjects:
Animals
Black raspberries
Cancer
Chemoprevention
Colon
Colonic Neoplasms - prevention & control
Esophageal Neoplasms - prevention & control
Esophagus
Freeze Drying
Fruit - chemistry
Hematology, Oncology and Palliative Medicine
Humans
Powders
Prevention
Rats
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Summary:Abstract Our laboratory is developing a food-based approach to the prevention of esophageal and colon cancer utilizing freeze-dried berries and berry extracts. Dietary freeze-dried berries were shown to inhibit chemically induced cancer of the rodent esophagus by 30–60% and of the colon by up to 80%. The berries are effective at both the initiation and promotion/progression stages of tumor development. Berries inhibit tumor initiation events by influencing carcinogen metabolism, resulting in reduced levels of carcinogen-induced DNA damage. They inhibit promotion/progression events by reducing the growth rate of pre-malignant cells, promoting apoptosis, reducing parameters of tissue inflammation and inhibiting angiogenesis. On a molecular level, berries modulate the expression of genes involved with proliferation, apoptosis, inflammation and angiogenesis. We have recently initiated clinical trials; results from a toxicity study indicated that freeze-dried black raspberries are well tolerated in humans when administered orally for 7 days at a dose of 45 g per day. Several Phase IIa clinical trials are underway in patients at high risk for esophagus and colon cancer; i.e., Barrett's esophagus, esophageal dysplasia and colonic polyps, to determine if berries will modulate various histological and molecular biomarkers of development of these diseases.
ISSN:1044-579X
1096-3650
DOI:10.1016/j.semcancer.2007.05.001