Increased Melatonin and Delayed Offset in Menopausal Depression: Role of Years Past Menopause, Follicle-Stimulating Hormone, Sleep End Time, and Body Mass Index

Context: The constellation of endocrine patterns accompanying menopausal depression remains incompletely characterized. Objective: Our objective was to test the hypothesis that the amplitude or phase (timing) of melatonin circadian rhythms differs in menopausal depressed patients (DP) vs. normal con...

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Bibliographic Details
Published in:The journal of clinical endocrinology and metabolism 2008-01, Vol.93 (1), p.54-60
Main Authors: Parry, Barbara L, Meliska, Charles J, Sorenson, Diane L, López, Ana M, Martínez, Luis F, Nowakowski, Sara, Hauger, Richard L, Elliott, Jeffrey A
Format: Article
Language:English
Subjects:
Biological and medical sciences
Body Mass Index
Circadian Rhythm - physiology
Depressive Disorder - blood
Endocrinopathies
Estradiol - blood
Feeding. Feeding behavior
Female
Follicle Stimulating Hormone - blood
Fundamental and applied biological sciences. Psychology
Humans
Luteinizing Hormone - blood
Medical sciences
Melatonin - blood
Menopause - blood
Middle Aged
Original
Polysomnography
Progesterone - blood
Sleep - physiology
Vertebrates: anatomy and physiology, studies on body, several organs or systems
Vertebrates: endocrinology
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Summary:Context: The constellation of endocrine patterns accompanying menopausal depression remains incompletely characterized. Objective: Our objective was to test the hypothesis that the amplitude or phase (timing) of melatonin circadian rhythms differs in menopausal depressed patients (DP) vs. normal controls women (NC). Design: We measured plasma melatonin every 30 min from 1800–1000 h in dim light (
ISSN:0021-972X
1945-7197
DOI:10.1210/jc.2006-2853