Recombination protein Tid1p controls resolution of cohesin-dependent linkages in meiosis in Saccharomyces cerevisiae

Sister chromatid cohesion and interhomologue recombination are coordinated to promote the segregation of homologous chromosomes instead of sister chromatids at the first meiotic division. During meiotic prophase in Saccharomyces cerevisiae, the meiosis-specific cohesin Rec8p localizes along chromoso...

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Bibliographic Details
Published in:The Journal of cell biology 2005-10, Vol.171 (2), p.241-253
Main Authors: Kateneva, Anna V, Konovchenko, Anton A, Guacci, Vincent, Dresser, Michael E
Format: Article
Language:English
Subjects:
Anaphase
Anaphase - physiology
Antibodies
Cell Cycle Proteins - genetics
Cell Cycle Proteins - metabolism
Cell division
Cell separation
Cells
Chromatids
Chromatin
Chromatin - metabolism
Chromosomal Proteins, Non-Histone - genetics
Chromosomal Proteins, Non-Histone - metabolism
Chromosomes
Chromosomes, Fungal - genetics
Chromosomes, Fungal - metabolism
Cohesins
DNA Helicases
DNA Repair Enzymes
Dressers
Fungal Proteins - genetics
Fungal Proteins - metabolism
Genetics
Meiosis
Meiosis - physiology
Nuclear Proteins - genetics
Nuclear Proteins - metabolism
Pachytene stage
Pachytene Stage - physiology
Phosphoproteins - genetics
Phosphoproteins - metabolism
Proteins
Recombinant Proteins - genetics
Recombinant Proteins - metabolism
Saccharomyces cerevisiae
Saccharomyces cerevisiae - cytology
Saccharomyces cerevisiae - physiology
Saccharomyces cerevisiae Proteins - genetics
Saccharomyces cerevisiae Proteins - metabolism
Sporulation
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Summary:Sister chromatid cohesion and interhomologue recombination are coordinated to promote the segregation of homologous chromosomes instead of sister chromatids at the first meiotic division. During meiotic prophase in Saccharomyces cerevisiae, the meiosis-specific cohesin Rec8p localizes along chromosome axes and mediates most of the cohesion. The mitotic cohesin Mcd1p/Scc1p localizes to discrete spots along chromosome arms, and its function is not clear. In cells lacking Tid1p, which is a member of the SWI2/SNF2 family of helicase-like proteins that are involved in chromatin remodeling, Mcd1p and Rec8p persist abnormally through both meiotic divisions, and chromosome segregation fails in the majority of cells. Genetic results indicate that the primary defect in these cells is a failure to resolve Mcd1p-mediated connections. Tid1p interacts with recombination enzymes Dmc1p and Rad51p and has an established role in recombination repair. We propose that Tid1p remodels Mcd1p-mediated cohesion early in meiotic prophase to facilitate interhomologue recombination and the subsequent segregation of homologous chromosomes.
ISSN:0021-9525
1540-8140
DOI:10.1083/jcb.200505020