Binding Kinetics of Darunavir to Human Immunodeficiency Virus Type 1 Protease Explain the Potent Antiviral Activity and High Genetic Barrier

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Bibliographic Details
Published in:Journal of Virology 2007-12, Vol.81 (24), p.13845-13851
Main Authors: DIERYNCK, Inge, DE WIT, Mieke, GUSTIN, Emmanuel, KEULEERS, Inge, VANDERSMISSEN, Johan, HALLENBERGER, Sabine, HERTOGS, Kurt
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Biological and medical sciences
Darunavir
Drug Resistance, Multiple, Viral
Drug Resistance, Viral
Fundamental and applied biological sciences. Psychology
Genetics
HIV Protease - genetics
HIV Protease - metabolism
HIV Protease Inhibitors - metabolism
HIV Protease Inhibitors - pharmacology
HIV-1 - drug effects
HIV-1 - enzymology
HIV-1 - genetics
Human immunodeficiency virus 1
Humans
Kinetics
Microbial Sensitivity Tests - methods
Microbiology
Miscellaneous
Molecular Sequence Data
Mutation
Sulfonamides - metabolism
Sulfonamides - pharmacology
Vaccines and Antiviral Agents
Virology
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Summary:Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue Spotlights in the Current Issue JVI About JVI Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy JVI RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0022-538X Online ISSN: 1098-5514 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to JVI .asm.org, visit: JVI       
ISSN:0022-538X
1098-5514
DOI:10.1128/JVI.01184-07