Peyer's patches: immunologic studies

The immune capabilities of the Peyer's patches have been investigated by the use of an in vitro system. Despite our failure to stimulate Peyer's patch lymphocytes in vivo it appears that Peyer's patches behave immunologically as peripheral lymphoid tissues. Cultures prepared from the...

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Bibliographic Details
Published in:The Journal of experimental medicine 1970-06, Vol.131 (6), p.1200-1210
Main Authors: Henry, C, Faulk, W P, Kuhn, L, Yoffey, J M, Fudenberg, H H
Format: Article
Language:English
Subjects:
Animals
Antibody Formation
Antibody-Producing Cells
Appendix - immunology
Culture Techniques
Ear, Inner - immunology
Epithelium
Erythrocytes - immunology
Goats
Immune Sera
Intestinal Mucosa - immunology
Intestine, Small - immunology
Lymphoid Tissue - immunology
Rabbits
Sheep
Spleen - immunology
Thymus Gland - immunology
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Summary:The immune capabilities of the Peyer's patches have been investigated by the use of an in vitro system. Despite our failure to stimulate Peyer's patch lymphocytes in vivo it appears that Peyer's patches behave immunologically as peripheral lymphoid tissues. Cultures prepared from the dissociated Peyer's patches of normal rabbits respond to sheep erythrocytes. The response is comparable to that obtained with spleen cultures from the same animals and is not dependent on the presence of the epithelial cells which line the lumen. Similar thymic cultures do not respond. Our experiments with cultures prepared from rabbits which have received one or two injections of SRC show that the Peyer's patches contain both IgM and IgG "memory" cells which have migrated from the spleen. The concentration of these cells in the spleen remains several hundredfold higher.
ISSN:0022-1007
1540-9538
DOI:10.1084/jem.131.6.1200