The yin and yang of intestinal epithelial cells in controlling dendritic cell function

Recent work suggests that dendritic cells (DCs) in mucosal tissues are "educated" by intestinal epithelial cells (IECs) to suppress inflammation and promote immunological tolerance. After attack by pathogenic microorganisms, however, "non-educated" DCs are recruited from nearby a...

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Bibliographic Details
Published in:The Journal of experimental medicine 2007-10, Vol.204 (10), p.2253-2257
Main Authors: Iliev, Iliyan D, Matteoli, Gianluca, Rescigno, Maria
Format: Article
Language:English
Subjects:
Animals
Commentaries
Dendritic Cells - immunology
Epithelial Cells - immunology
Humans
Inflammation - immunology
Inflammation - pathology
Intestines - immunology
Intestines - pathology
Yin-Yang
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Summary:Recent work suggests that dendritic cells (DCs) in mucosal tissues are "educated" by intestinal epithelial cells (IECs) to suppress inflammation and promote immunological tolerance. After attack by pathogenic microorganisms, however, "non-educated" DCs are recruited from nearby areas, such as the dome of Peyer's patches (PPs) and the blood, to initiate inflammation and the ensuing immune response to the invader. Differential epithelial cell (EC) responses to commensals and pathogens may control these two tolorogenic and immunogenic functions of DCs.
ISSN:0022-1007
1540-9538
1892-1007
DOI:10.1084/jem.20062535