A case-control study of presentations in general practice before diagnosis of coeliac disease

A case-control study of presentations in general practice before diagnosis of coeliac disease

Delay in the diagnosis of coeliac disease prolongs morbidity and may increase mortality. Little is known about presentations in general practice that may predict a subsequent diagnosis of coeliac disease. To examine presentations in general practice during the 5 years prior to diagnosis of coeliac d...

Full description

Saved in:
Bibliographic Details
Published in:British journal of general practice 2007-08, Vol.57 (541), p.636-642
Main Authors: Cannings-John, Rebecca, Butler, Christopher C, Prout, Hayley, Owen, Diane, Williams, Della, Hood, Kerenza, Crimmins, Rosemary, Swift, Gillian
Format: Article
Language:eng
Subjects:
Adult
Aged
Anemia - complications
Anxiety Disorders - complications
Case-Control Studies
Celiac Disease - diagnosis
Celiac Disease - psychology
Depressive Disorder - complications
Diarrhea - complications
Early Diagnosis
Family Practice
Female
Humans
Male
Middle Aged
Multivariate Analysis
Original Papers
Referral and Consultation
Wales
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Delay in the diagnosis of coeliac disease prolongs morbidity and may increase mortality. Little is known about presentations in general practice that may predict a subsequent diagnosis of coeliac disease. To examine presentations in general practice during the 5 years prior to diagnosis of coeliac disease. A case-control study with each biopsy-proven coeliac disease case matched by age, sex, and general practice to an average of two controls. Thirty-seven general practices in south-east Wales. Cases were identified via a secondary care clinic and controls recruited from the general practices of cases. General practice clinical records of both cases and controls were analysed to determine frequency of consultations, presenting symptoms, diagnoses, referrals, and investigations during the 5 years prior to diagnosis. Cases (n = 68) had an increased number of consultations compared with controls (n = 160) during the 5 years prior to diagnosis (mean difference five consultations, P = 0.001). Three clinical features were independently associated with subsequent diagnosis of coeliac disease: depression and/or anxiety (odds ratio [OR] = 2.5, 95% confidence interval [CI] = 1.1 to 5.7, P = 0.031); diarrhoea (OR = 4.5, 95% CI = 2.0 to 10.0, P
ISSN:0960-1643
1478-5242