Patterns of MRI atrophy in tau positive and ubiquitin positive frontotemporal lobar degeneration

We applied optimised voxel based morphometry (VBM) to brain MRIs from autopsy proven cases of tau positive frontotemporal lobar degeneration (FTLD-T, n = 6), ubiquitin and TDP-43 positive/tau negative FTLD (FTLD-U, n = 8) and cognitively normal controls (n = 61). The analysis revealed that FTLD-T an...

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Bibliographic Details
Published in:Journal of neurology, neurosurgery and psychiatry neurosurgery and psychiatry, 2007-12, Vol.78 (12), p.1375-1378
Main Authors: Kim, E J, Rabinovici, G D, Seeley, W W, Halabi, C, Shu, H, Weiner, M W, DeArmond, S J, Trojanowski, J Q, Gorno-Tempini, M L, Miller, B L, Rosen, H J
Format: Article
Language:English
Subjects:
Aged
Atrophy - pathology
Autopsy
Biological and medical sciences
Caudate Nucleus - anatomy & histology
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Dementia
Dementia - complications
Dementia - diagnosis
Dementia - etiology
Dementia - metabolism
Dementia - pathology
Disease
Error correction & detection
Female
Humans
Investigative techniques, diagnostic techniques (general aspects)
Magnetic Resonance Imaging
Male
Medical sciences
Nervous system
Neurology
Neuropsychological Tests
Pathogenesis
Pathology
Putamen - anatomy & histology
Radiodiagnosis. Nmr imagery. Nmr spectrometry
Severity of Illness Index
Short Report
tau Proteins - metabolism
Ubiquitin - metabolism
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Summary:We applied optimised voxel based morphometry (VBM) to brain MRIs from autopsy proven cases of tau positive frontotemporal lobar degeneration (FTLD-T, n = 6), ubiquitin and TDP-43 positive/tau negative FTLD (FTLD-U, n = 8) and cognitively normal controls (n = 61). The analysis revealed that FTLD-T and FTLD-U both show atrophy in the frontal cortex and striatum, but striatal atrophy is more severe in FTLD-T. Manual region of interest tracing of caudate and putamen volumes confirmed the VBM findings. These anatomical differences may help distinguish between FTLD spectrum pathological subtypes in vivo.
ISSN:0022-3050
1468-330X
DOI:10.1136/jnnp.2006.114231