The Complete Genome Sequence of Chromobacterium violaceum Reveals Remarkable and Exploitable Bacterial Adaptability

Chromobacterium violaceum is one of millions of species of free-living microorganisms that populate the soil and water in the extant areas of tropical biodiversity around the world. Its complete genome sequence reveals (i) extensive alternative pathways for energy generation, (ii) ≈500 ORFs for tran...

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Published in:Proceedings of the National Academy of Sciences - PNAS 2003-09, Vol.100 (20), p.11660-11665
Main Authors: Ana Tereza Ribeiro de Vasconcelos, de Almeida, Darcy F., Hungria, Mariangela, Guimarães, Claudia Teixeira, Antônio, Regina Vasconcellos, Almeida, Francisca Cunha, Luiz G. P. de Almeida, de Almeida, Rosana, Alves-Gomes, José Antonio, Araripe, Julia, Magnólia Fernandes Florêncio de Araújo, Azevedo, Vasco, Baptista, Alessandra Jorge, Luiz Artur Mendes Bataus, Jacqueline da Silva Batista, Beló, André, van den Berg, Cássio, Bogo, Maurício, Bonatto, Sandro, Bordignon, Juliano, Brigido, Marcelo Macedo, Brito, Cristiana Alves, Brocchi, Marcelo, Burity, Helio Almeida, Camargo, Anamaria Aranha, Divina das Dores de Paula Cardoso, Carneiro, Newton Portilho, Cláudia Márcia Benedetto Carvalho, Júlio Cézar de Mattos Cascardo, Cavada, Benildo Sousa, Ligia Maria O. Chueire, Creczynski-Pasa, Tânia Beatriz, Fagundes, Nelson, Falcão, Clarissa Lima, Fantinatti, Fabiana, Farias, Izeni Pires, Ferrari, Lilian Pereira, Ferro, Jesus Aparecido, Maria Inês Tiraboschi Ferro, Franco, Gloria Regina, Nara Suzy Aguiar de Freitas, Furlan, Luiz Roberto, Gazzinelli, Ricardo Tostes, Gomes, Eliane Aparecida, Grangeiro, Thalles Barbosa, Grattapaglia, Dario, Grisard, Edmundo Carlos, Hanna, Ebert Seixas, Jardim, Sílvia Neto, Laurino, Jomar, Lélia Cristina Tenório Leoi, Lucymara Fassarella Agnez Lima, Maria de Fatima Loureiro, Maria do Carmo Catanho Pereira de Lyra, Humberto Maciel França Madeira, Manfio, Gilson Paulo, Maranhão, Andrea Queiroz, Sônia Marli Zingaretti di Mauro, Silvia Regina Batistuzzo de Medeiros, Rosely de Vasconcellos Meissner, Miguel Angelo Martins Moreira, Fabrícia Ferreira do Nascimento, Nicolás, Marisa Fabiana, Oliveira, Sergio Costa, Roger Ferreira Cury Paixão, Parente, Juliana Alves, Fabio de Oliveira Pedrosa, Sergio Danilo Junho Pena, Pereira, José Odair, Pereira, Maristela, Luciano da Silva Pinto, Jorge Ivan Rebelo Porto, Potrich, Deise Porto, Ramalho-Neto, Cicero Eduardo, Alessandra Maria Moreira Reis, Rigo, Liu Um, Rondinelli, Edson, Elen Bethleen Pedraça do Santos, Santos, Fabrício R., Maria Paula Cruz Schneider, Seuanez, Hector N., Ana Maria Rodrigues Silva, Artur Luiz da Costa da Silva, Silva, Denise Wanderlei, Silva, Rosane, Isabella de Carmo Simões, Simon, Daniel, Célia Maria de Almeida Soares, Renata de Bastos Ascenço Soares, Souza, Emanuel Maltempi, Kelly Rose Lobo de Souza, Souza, Rangel Celso, Maria Berenice Reynaud Steffens, Steindel, Mário, Teixeira, Santuza Ribeiro, Urmenyi, Turan, Vettore, André, Wassem, Roseli, Zaha, Arnaldo, Andrew John George Simpson
Format: Article
Language:English
Subjects:
Adaptation, Physiological
Bacteriology
Biological Sciences
Biology
Biotechnology
Chromobacterium - genetics
Chromobacterium - physiology
Cogs
Genome, Bacterial
Genomes
Genomics
Infections
Lipid metabolism
Microbiology
Molecular genetics
Molecular Sequence Data
Open Reading Frames
Protein metabolism
Rainforests
School campuses
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Summary:Chromobacterium violaceum is one of millions of species of free-living microorganisms that populate the soil and water in the extant areas of tropical biodiversity around the world. Its complete genome sequence reveals (i) extensive alternative pathways for energy generation, (ii) ≈500 ORFs for transport-related proteins, (iii) complex and extensive systems for stress adaptation and motility, and (iv) widespread utilization of quorum sensing for control of inducible systems, all of which underpin the versatility and adaptability of the organism. The genome also contains extensive but incomplete arrays of ORFs coding for proteins associated with mammalian pathogenicity, possibly involved in the occasional but often fatal cases of human C. violaceum infection. There is, in addition, a series of previously unknown but important enzymes and secondary metabolites including paraquat-inducible proteins, drug and heavy-metal-resistance proteins, multiple chitinases, and proteins for the detoxification of xenobiotics that may have biotechnological applications.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.1832124100