Diffusion tensor imaging and voxel based morphometry study in early progressive supranuclear palsy

Background: A comprehensive characterisation of grey and white matter changes in progressive supranuclear palsy (PSP), the second most common extrapyramidal syndrome after Parkinson disease, is still not available. Objective: To evaluate grey and white matter changes in mild PSP patients by voxel ba...

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Bibliographic Details
Published in:Journal of neurology, neurosurgery and psychiatry neurosurgery and psychiatry, 2006-04, Vol.77 (4), p.457-463
Main Authors: Padovani, A, Borroni, B, Brambati, S M, Agosti, C, Broli, M, Alonso, R, Scifo, P, Bellelli, G, Alberici, A, Gasparotti, R, Perani, D
Format: Article
Language:English
Subjects:
Activities of daily living
Aged
Anisotropy
Anterior Thalamic Nuclei - pathology
BADL
basic activities of daily living
Biological and medical sciences
Brain research
CDR
Cerebral Cortex - pathology
cerebrospinal fluid
clinical dementia rating scale
Cognition Disorders - diagnosis
Cognition Disorders - etiology
CSF
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Dementia
Diagnostic and Statistical Manual of Mental Disorders
Diffusion Magnetic Resonance Imaging
diffusion tensor imaging
Disease
DSM-IV
DTI
false discovery rate
FBI
FDR
Female
fourth edition
fractional anisotropy
frontal behavioural inventory
full width at half maximum
FWHM
grey matter
Hippocampus - pathology
Humans
IADL
instrumental activities of daily living
Investigative techniques, diagnostic techniques (general aspects)
Magnetic resonance imaging
Male
Medical imaging
Medical sciences
mini-mental state examination
MMSE
MNI
Montreal Neurological Institute
Motor Cortex - pathology
Nervous system
Neuroimaging
Neurological disorders
Neurology
neuropsychiatric inventory
Neuropsychological Tests
NPI
Parkinson's disease
Prefrontal Cortex - pathology
progressive supranuclear palsy
PSP
Radiodiagnosis. Nmr imagery. Nmr spectrometry
Severity of Illness Index
Supranuclear Palsy, Progressive - complications
Supranuclear Palsy, Progressive - pathology
unified Parkinson disease rating scale
UPDRS
VBM
voxel based morphometry
white matter
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Summary:Background: A comprehensive characterisation of grey and white matter changes in progressive supranuclear palsy (PSP), the second most common extrapyramidal syndrome after Parkinson disease, is still not available. Objective: To evaluate grey and white matter changes in mild PSP patients by voxel based morphometry (VBM) and diffusion tensor imaging (DTI), respectively. Methods: 14 mild PSP patients and 14 healthy controls entered the study and underwent a clinical and neuropsychological evaluation according with a standardised assessment. Each subject had a structural magnetic resonance imaging (MRI) study. Processing analysis of MRI data was carried out according to optimised VBM and fractional anisotropy was determined. Results: Compared with the controls, in PSP patients VBM analysis showed a significant clusters of reduced grey matter in premotor cortex, frontal operculum, anterior insula, hippocampus, and parahippocampal gyrus, bilaterally. With regard to subcortical brain regions, the pulvinar, dorsomedial and anterior nuclei of the thalamus, and superior and inferior culliculum were affected bilaterally. A bilateral decrease in fractional anisotropy in superior longitudinal fasciculus, anterior part of corpus callosum, arcuate fascicolus, posterior thalamic radiations, and internal capsule, probably involving the cortico-bulbar tracts, was present in PSP patients. Conclusions: These data provide evidence for both grey and white matter degeneration in PSP from the early disease stage. These structural changes suggest that atrophy of cortical and subcortical structures and neurodegeneration of specific fibre tracts contribute to neurological deficits in PSP.
ISSN:0022-3050
1468-330X
DOI:10.1136/jnnp.2005.075713