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CENTRAL CARDIOVASCULAR EFFECTS OF NARCOTIC ANALGESICS AND ENKEPHALINS IN RATS
1 The cardiovascular effects of morphine, fentanyl, [d‐Ala2]‐met‐enkephalinamide were analyzed after intracisternal injection in anaesthetized rats. Pao2 was measured as an index of respiratory function. 2 At low doses in spontaneously breathing rats, morphine, fentanyl and [d‐Ala2]‐met‐enkephalinam...
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Published in: | British journal of pharmacology 1980-01, Vol.71 (2), p.365-369 |
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Main Authors: | , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | 1
The cardiovascular effects of morphine, fentanyl, [d‐Ala2]‐met‐enkephalinamide were analyzed after intracisternal injection in anaesthetized rats. Pao2 was measured as an index of respiratory function.
2
At low doses in spontaneously breathing rats, morphine, fentanyl and [d‐Ala2]‐met‐enkephalinamide induced a pressor response with slight tachycardia and no significant change in Pao2.
3
The pressor response appeared to be due to activation of opiate receptors and mediated through the sympathetic nervous system.
4
High doses of morphine and [d‐Ala2]‐met‐enkephalinamide induced a biphasic effect with a secondary hypotension associated with bradycardia in spontaneously breathing rats. A marked reduction in Pao2 was found during the depressor phase.
5
High doses of [d‐Ala2]‐met‐enkephalinamide produced only a pressor response in artificially‐ventilated rats with no signs of secondary hypotension.
6
Our data support the idea that morphinomimetic agents are centrally pressor at low doses in the rat. The respiratory depression observed with high doses may be the cause of hypotension. |
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ISSN: | 0007-1188 1476-5381 |
DOI: | 10.1111/j.1476-5381.1980.tb10949.x |