The impact of age on bispectral index values and EEG bispectrum during anaesthesia with desflurane and halothane in children

The relationship between end-tidal sevoflurane concentration, bispectral index (BIS) and the EEG bispectrum in children appears to be age dependent. The aim of this study was to quantify the BIS values at 1 MAC (minimum alveolar concentration) for desflurane and halothane, and explore the relationsh...

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Bibliographic Details
Published in:British journal of anaesthesia : BJA 2006-04, Vol.96 (4), p.480-485
Main Authors: Tirel, O, Wodey, E, Harris, R, Bansard, J.Y., Ecoffey, C, Senhadji, L
Format: Article
Language:English
Subjects:
Adolescent
Age Factors
anaesthesia
anaesthetics volatile
anaesthetics volatile, desflurane
anaesthetics volatile, halothane
Anesthesia
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Anesthetics, Inhalation - pharmacology
Biological and medical sciences
bispectral index
Body Weight - physiology
Child
Child, Preschool
children
desflurane
EEG bispectrum
Electrocardiography - drug effects
Electroencephalography - drug effects
Female
halothane
Halothane - pharmacology
Humans
Infant
Isoflurane - analogs & derivatives
Isoflurane - pharmacology
Male
Medical sciences
monitoring
monitoring, bispectral index
monitoring, EEG bispectrum
Monitoring, Intraoperative - methods
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Summary:The relationship between end-tidal sevoflurane concentration, bispectral index (BIS) and the EEG bispectrum in children appears to be age dependent. The aim of this study was to quantify the BIS values at 1 MAC (minimum alveolar concentration) for desflurane and halothane, and explore the relationship with age for these anaesthetic agents in children. ECG, EEG and BIS were recorded continuously in 90 children aged 6–170 months requiring anaesthesia for elective surgery. Fifty children were anaesthetized with desflurane, and 40 children with halothane. Recordings were performed through to a steady state of 2 MAC, and thereafter at 1 and 0.5 MAC, respectively. The bispectrum of the EEG was estimated using MATLAB© software. A multiple correspondence analysis (MCA) was used. At a steady state of 1 MAC, BIS values were significantly higher with halothane 62 (43–80) than desflurane 34 (18–64). BIS values were significantly correlated with age in both groups: DES (r2=0.57; P
ISSN:0007-0912
1471-6771
DOI:10.1093/bja/ael034